Registration Dossier
Registration Dossier
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EC number: 204-370-6 | CAS number: 120-11-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- direct peptide reactivity assay (DPRA)
- Justification for non-LLNA method:
- In vitro study performed.
Test material
- Reference substance name:
- Benzyl 2-methoxy-4-prop-1-enylphenyl ether
- EC Number:
- 204-370-6
- EC Name:
- Benzyl 2-methoxy-4-prop-1-enylphenyl ether
- Cas Number:
- 120-11-6
- Molecular formula:
- C17H18O2
- IUPAC Name:
- benzyl 2-methoxy-4-prop-1-enylphenyl ether
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- Homogeneous 100 mM stock solutions are obtained with acetonitrile, isopropanol and acetone. However when diluted in peptide buffer, the test item precipitates in all cases. In these conditions, OCDE 442C stipulates that only a positive DPRA prediction could be taken into account.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Homogeneous 100 mM stock solutions are obtained with acetonitrile, isopropanol and acetone. However when diluted in peptide buffer, the test item precipitates in all cases. In these conditions, OCDE 442C stipulates that only a positive DPRA prediction could be taken into account.
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