Registration Dossier
Registration Dossier
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EC number: 295-374-7 | CAS number: 92044-94-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 November 2017 to 08 February 2018 additional analyses 22 to 23 February 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- non-GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- column elution method
- Water solubility:
- < 4.27 µg/L
- Conc. based on:
- test mat.
- Temp.:
- 19.3 °C
- pH:
- 7
- Remarks on result:
- other: HPLC result solubility < LOQ
- Water solubility:
- 5.362 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 19.3 °C
- pH:
- 7
- Remarks on result:
- other: GC result
- Details on results:
- In a pre-test the solubility was found to be < 1 g/L
No temperature dependence or chemical instability of the material was observed during this study. - Conclusions:
- The water solubility is <4.27 µg/L (HPLC) and 5.362 mg/L (GC-FID)
- Executive summary:
When run on the HPLC with UV detector both of the columns samples gave negative results. With the negative result, we can assume that the solubility is lower than the Limit of Detection (LOD=4.27µg/L). Therefore thespecified validity criteria could not be satisfied for this test (between-column final concentrations variation being <30%).
The GC-FID analysis was run on both of the column samples and was able to detect with a Limit of Detection of 0.71 mg/L. Column A, run at 12.5 mL/hr, produced a solubility of 5.443 mg/L and Column B, run at 25 mL/hr, produced a solubility of 5.281 mg/L.. The specified validity criteria was that between-column final concentrations variation should be <30%, this was satisfied for this test as %SD between columns A and B was 2.13%.
No temperature dependence or chemical instability of the material was observed during this study. The water solubility of the substance was found to be 5.362 mg/L under the conditions of this test.
Reference
see attachment
For the HPLC method the between-column final concentrations could not be determined.
For the GC method the between-column final concentrations was 2.13%.
Description of key information
A water solubility test using two different analytical methods was performed. The water solubility is <4.27 µg/L (HPLC) and 5.362 mg/L (GC-FID).
Key value for chemical safety assessment
- Water solubility:
- 5.36 mg/L
- at the temperature of:
- 19.3 °C
Additional information
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