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EC number: 295-374-7
CAS number: 92044-94-5
A GLP study according to OECD 211 is available for
Lanolin alcohol (Harris 2013). Due to the low aqueous
solubility and complex nature of the test item, Water
Accommodated Fraction (WAF) were prepared. Based on the
results of a preliminary range-finding test, Daphnia
magna were exposed (10 replicates of a single daphnid
per group) to a Water Accommodated Fraction (WAF) of the
test item at single nominal loading rate of 100 mg/L for
a period of 21 days. Analysis of the 100 mg/L loading
rate WAF on days 0, 5, 14, 16 and 19 (fresh media)
showed measured concentrations to range from 0.018 to
0.054 mg/L. A decline in measured concentration was
observed in the corresponding old media on days 2, 7,
16, 19 and 21 to between less than the limit of
quantification (LOQ) of the analytical method employed,
which was determined to be 0.0098 mg/L and 0.017 mg/L.
Given that the toxicity cannot be attributed to a single
component or a mixture of components, but to the test
item as a whole, the results were based on the nominal
loading rate only. The "No Observed Effect Loading Rate"
(NOEL) was 100 mg/L loading rate WAF as there were no
significant mortalities (immobilization) observed in the
parental generation (P1) and there were no significant
differences (P≥0.05) in terms of the number of live
young produced per adult when compared to the control
after 21 days.
No studies on the ester of lanolin alcohols and fatty acids are
available. As the substance can be hydrolysed abiotically and is
expected to be hydrolysed by esterases, the toxicity of the hydrolysis
products lanolin alcohol is representative for the toxicity of the
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