Registration Dossier
Registration Dossier
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EC number: 214-482-7 | CAS number: 1134-23-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- no
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- Cycloate
- IUPAC Name:
- Cycloate
- Details on test material:
- Cycloate
Constituent 1
Results and discussion
Test results
- Key result
- Sex:
- not specified
- Genotoxicity:
- negative
- Remarks:
- QSAR
- Remarks on result:
- not measured/tested
- Remarks:
- QSAR
Applicant's summary and conclusion
- Conclusions:
- ACD/Percepta genotoxicity (micronucleus in vivo) prediction is NEGATIVE, based on a positive prediction probability equal to 0.154.
In support to the above prediction, it is noted that ACD/Percepta did not identify relevant structural alerts for clastogenicity.
It is highlighted that a negative experimental data on micronucleus in vivo test (mouse/male and female/bone marrow) for the target compound Cycloate is available (CCRIS
Database). - Executive summary:
ACD/Percepta genotoxicity (micronucleus in vivo) prediction is NEGATIVE,
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