Registration Dossier
Registration Dossier
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EC number: 214-482-7 | CAS number: 1134-23-2
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in chemico
- Type of information:
- (Q)SAR
- Remarks:
- QSAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Remarks:
- QSAR
- Justification for type of information:
- QSAR
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- QSAR
- GLP compliance:
- no
Test material
- Reference substance name:
- Cycloate
- IUPAC Name:
- Cycloate
- Details on test material:
- Cycloate
Constituent 1
In chemico test system
- Details on the study design:
- See it in the attached document.
Results and discussion
In vitro / in chemico
Results
- Key result
- Remarks on result:
- positive indication of skin sensitisation
- Remarks:
- QSAR
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- Prediction: POSITIVE, based on a positive prediction probability greater than 0.5, in the range 0.911-0.945.
The WoE prediction was based on the Global model and on the identification of chemotype alert of concern for skin senstitization, i.e. bond:CS_sulfide_SC. - Executive summary:
Prediction: POSITIVE.
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