Registration Dossier
Registration Dossier
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EC number: 205-119-3 | CAS number: 133-74-4
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited
Data source
Reference
- Reference Type:
- publication
- Title:
- Fish Acute (LC50) model SarPy/IRFMN v1.0.2
- Author:
- Laboratory of Environmetal Chemestry and Toxicology of Mario negri Institute of Pharmacological Research
- Year:
- 2 018
- Bibliographic source:
- Vega v.1.1.4
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Test material
- Reference substance name:
- 2-amino-5-chlorobenzenesulphonic acid
- EC Number:
- 205-119-3
- EC Name:
- 2-amino-5-chlorobenzenesulphonic acid
- Cas Number:
- 133-74-4
- Molecular formula:
- C6H6ClNO3S
- IUPAC Name:
- 2-amino-5-chlorobenzenesulphonic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- The SMILES included in the reference substance linked in Section 1 (General information) was used as model input.
Sampling and analysis
- Analytical monitoring:
- not required
Study design
- Test type:
- other: QSAR
Results and discussion
Effect concentrations
- Dose descriptor:
- LC50
- Effect conc.:
- >= 10 - <= 100 mg/L
- Conc. based on:
- other: QSAR
- Remarks on result:
- other: QSAR
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Conclusions:
- The predicted toxicity class is 3 (between 10 and 100 mg/ml).
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