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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation, other
Remarks:
in silico
Type of information:
(Q)SAR
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Documentation about the justification is provided in attachment.

Data source

Reference
Reference Type:
publication
Title:
Assessment of the eye irritating properties of chemicals by applying alternatives to the Draize rabbit eye test: the use of QSARs and in vitro tests for the classification of eye irritation.
Author:
Gerner, I., Liebsch, M., Spielmann, H.
Year:
2005
Bibliographic source:
Alternatives to Laboratory Animals 33, 215-237.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Test material

Constituent 1
Chemical structure
Reference substance name:
2-amino-5-chlorobenzenesulphonic acid
EC Number:
205-119-3
EC Name:
2-amino-5-chlorobenzenesulphonic acid
Cas Number:
133-74-4
Molecular formula:
C6H6ClNO3S
IUPAC Name:
2-amino-5-chlorobenzenesulphonic acid
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
The SMILES included in the reference substance linked in Section 1 (General information) was used as model input.

Test animals / tissue source

Species:
other: QSAR

Results and discussion

In vivo

Results
Irritation parameter:
other: QSAR prediction
Remarks on result:
other: not corrosive to skin/eye
Irritant / corrosive response data:
The substance is predicted not to be corrosive to skin/eye.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The substance should not be classified as corrosive to eye. Study results do not allow to exclude eye irritation; therefore, data are deemed to be inconclusive.