Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 205-119-3 | CAS number: 133-74-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in silico
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Documentation about the justification is provided in attachment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Use of Physicochemical Property Limits to Develop Rules for Identifying Chemical Substances with no Skin Irritation or Corrosion Potential
- Author:
- Ingrid Gerner, Kerstin Schlegel, John D. Walker, and Etje Hulzebosc
- Year:
- 2 004
- Bibliographic source:
- QSAR Comb. Sci. 2004, 23, pp.726-733
- Reference Type:
- publication
- Title:
- The Skin Irritation Corrosion Rules Estimation Tool (SICRET)
- Author:
- John D. Walker, Ingrid Gerner, Etje Hulzebos, Kerstin Schlegel
- Year:
- 2 005
- Bibliographic source:
- QSAR Comb. Sci. 2005, 24, pp.378-384
- Reference Type:
- publication
- Title:
- Use of structural alerts to develop rules for identifying chemical substances with skin irritation or skin corrosion potential
- Author:
- Etje Hulzebos, John D. Walker, Ingrid Gerner, and Kerstin Schlegel
- Year:
- 2 005
- Bibliographic source:
- QSAR Comb. Sci. 2005, 24, pp.332-342
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.
Test material
- Reference substance name:
- 2-amino-5-chlorobenzenesulphonic acid
- EC Number:
- 205-119-3
- EC Name:
- 2-amino-5-chlorobenzenesulphonic acid
- Cas Number:
- 133-74-4
- Molecular formula:
- C6H6ClNO3S
- IUPAC Name:
- 2-amino-5-chlorobenzenesulphonic acid
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- The SMILES included in the reference substance linked in Section 1 (General information) was used as model input.
Test animals
- Species:
- other: QSAR
Results and discussion
In vivo
Results
- Irritation parameter:
- other: QSAR prediction
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The substance is predicted not to be corrosive or irritant to the skin.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance should not be classified as irritant to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
