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EC number: 480-890-9
CAS number: 906532-68-1
Concurrent Cytotoxicity analysis of Everzol Orange ED-G Crude in Chinese
Hamster Ovary Cells
Summary of Chromosome aberrations in Chinese Hamster Ovary cells
The chromosome aberration assay was conducted in three test
schemes: 3-hour exposure both with and without S9 activation (schemes I
and II) and 20-hour continuous exposure without S9 (scheme III). Results
were conducted in duplicate cultures and with negative control and
positive controls concurrently. 100 metaphases for each culture and 200
metaphases for each treatment were scored. Results showed that percents
of aberrant cells induced by negative control in the scheme I, II and
III were 1%, 0% and 0.5%. The positive control induced significant
increases in percents of aberrant cells over the corresponding negative
control. Everzol Orange ED-G did not significantly increase the
frequencies of structural chromosome aberration in the schemes I and
III. However, the frequencies of structural chromosome aberration in the
scheme II, at concentration of 150 and 500 um/mL in the 3 hr incubation
have significantly increased.
In conclusion, Everzol Orange ED-G crude induced structural
chromosome aberration at the concentration of 150 and 500 μg/mL at the
presence of S9 for 3-hr treatment. The concentration-response analysis
and trend probability were conducted in the 3-hr treatment with S9 and
results showed lacking in concentration response.
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