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EC number: 241-698-9 | CAS number: 17696-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- The source compound Benzyl 4-hydroxybenzoate (EC 202-311-9, CAS 94-18-8) is considered a suitable read across partner for the target substance Phenyl 4-hydroxybenzoate (EC 241-698-9, CAS 17696-62-7). This read-across is based on the hypothesis that source and target substances have similar toxicological properties because:
- structural similarity of the target and the source substances (the presence or absence of additional functional groups or substituents that could influence the behaviour of a chemical),
- similarity in physico-chemical profile of the source and target substances (water solubility, partitioning behaviour (log Kow value))
Both substances are structural homologues regarding the functional groups at the ester (phenyl vs benzyl group). Both esthers have similar physico-chemical properties. Both are moderately/poorly water soluble (108 g/L vs 0.05 mg/L), exhibit similar log Kow values (3.97 vs 3.21), have similar boiling points (355 °C vs 241 °C) and vapour pressure (3.37x10-6 mm Hg vs 8.17x10-6 mm Hg). - Reason / purpose for cross-reference:
- read-across source
- Duration:
- 10 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 10 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 10-d NOEC of the test item to Daphnia magna was determined to be 1.0 mg/L for the endpoint reproduction and < 0.1 mg/L for the endpoint growth.
- Executive summary:
The 10-day-chronic toxicity of benzyl 4-hydroxybenzoate to Daphnia magna was studied under static renewal conditions. Test species were exposed to control, solvent control, and test chemical at nominal concentrations of 2.0 / 1.0 / 0.5 / 0.25 / 0.125 mg a.i./L. The 10-day NOEC based on reproduction was 1.0 mg a.i./L. The sublethal effects included were reproduction and growth. Production of offsprings in the treated groups indicated that the test item had an effect on the reproduction at concentrations of 2.0 mg a.i./L and higher. The most sensitive end point was growth with a 10-d LOEC of 0.1 mg/L. A NOEC for the endpoint growth could not be determined, because the tested concentrations were not low enough.
This study is classified as acceptable and satisfies the guideline requirements for a chronic toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism Age (e.g. 1stinstar): < 24 h
Test Type (Flowthrough Static, Static Renewal): Static renewal
Endpoint(s) Effected: reproduction
NOEC: 1.0 mg a.i./L
LOEC: 2.0 mg a.i./L
Endpoint(s) Effected: growth
NOEC: < 0.1 mg a.i./L
LOEC: 0.1 mg a.i./L
This information is used in a read-across approach in the assessment of the target substance.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- The source compound Benzyl 4-hydroxybenzoate (EC 202-311-9, CAS 94-18-8) is considered a suitable read across partner for the target substance Phenyl 4-hydroxybenzoate (EC 241-698-9, CAS 17696-62-7). This read-across is based on the hypothesis that source and target substances have similar toxicological properties because:
- structural similarity of the target and the source substances (the presence or absence of additional functional groups or substituents that could influence the behaviour of a chemical),
- similarity in physico-chemical profile of the source and target substances (water solubility, partitioning behaviour (log Kow value))
Both substances are structural homologues regarding the functional groups at the ester (phenyl vs benzyl group). Both esthers have similar physico-chemical properties. Both are moderately/poorly water soluble (108 g/L vs 0.05 mg/L), exhibit similar log Kow values (3.97 vs 3.21), have similar boiling points (355 °C vs 241 °C) and vapour pressure (3.37x10-6 mm Hg vs 8.17x10-6 mm Hg). - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.84 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In a study conducted according to the OECD guideline 211 (version 2008) Daphnia magna were exposed to benzyl 4-hydroxy benzoate for 21 days and the number of neonates was evaluated. A 21-d NOEC of 0.84 mg/L was determined for the endpoint reproduction.
- Executive summary:
The 21-day-chronic toxicity of benzyl 4-hydroxybenzoate to Daphnia magna was studied under static renewal conditions according to the OECD guiedline 211 (version 2008). Test species were exposed to control, and test chemical at five different concentrations (exact amount not specified in paper). The 21-day NOEC based on reproduction was 0.84 mg a.i./L. The sublethal effects included were reproduction (cummulative number of neonates). Production of offspring in the treated groups indicated that the test item had an effect on the reproduction at concentrations of above 0.84 mg a.i./L.
This study is classified as acceptable and satisfies the guideline requirements for a chronic toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism Age (e.g. 1stinstar): < 24 h
Test Type (Flowthrough Static, Static Renewal): Static renewal
Endpoint(s) Effected: reproduction
NOEC: 0.84 mg a.i./L
LOEC: not reported
Referenceopen allclose all
Description of key information
In a study conducted according to the OECD guideline 211 (version 2008) Daphnia magna were exposed to benzyl 4-hydroxy benzoate for 21 days and the number of neonates was evaluated. A 21-d NOEC of 0.84 mg/L was determined for the endpoint reproduction.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.84 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.