Registration Dossier
Registration Dossier
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EC number: 241-698-9 | CAS number: 17696-62-7
Endpoint summary
Administrative data
Description of key information
Three trophic levels (fish, daphnia, algae) are covered by the toxicity data set and can be used for hazard assessment. Fish species were observed to be the most sensitive species:
Lowest value acute:
96-h LC50 (Oryzias latipes) = 0.73 mg/L
Lowest value chronic:
NOEC from VTG assay (14 -d exposure of Pimephales promelas) = 0.02 mg/L
Additional information
According to regulation (EC) No 1907/2006 toxicity tests with fish are not required for a tonnage of 1 to 10 tpa. Nevertheless, according to Article 12 of the mentioned regulation shall include all physicochemical, toxicological and ecotoxicological information that is relevant and available to the registrant. The available results from the fish studies reveal that fish is the most sensitive organism towards phenyl 4-benzoate and are therefore included in the present dossier and considered for classification according to Regulation (EC) No 1272/2008.
Two publications on short-term toxicity for fish are available indicating the following effect values:
The key study from Yamamoto et al. revealed a 96 h LC50 for Oryzias latipes. In the exposure experiment from Dobbins et al. (2009) a 48 h LC 50 of 3.3 mg/L was determined for Pimephales promelas, which is in the same range as the LC50 derived by Yamamoto et al. a 96 h LC50 for Oryzias latipas equalling 0.73 mg/L.
The lower value was set as key value for acute toxicity.
The key value for long-term toxicity to fish results from a VTG assay (14 -d exposure of male medaka). The effect concentrations from Yamamoto et al. (2011) were determined as follows:
LOEC: 20 µg/L a.i./L
NOEC: 100 µg a.i./L
A second long-term study (7 -day exposure of Pimephales promelas larvae, Dobbins et al. 2009) indicates similar values:
LOEC: 1.7 mg/L
NOEC: 0.85 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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