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Vapour pressure

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vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 May 2016 - 09 Sep 2016
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Composition 0
according to
OECD Guideline 104 (Vapour Pressure Curve)
according to
EU Method A.4 (Vapour Pressure)
according to
EPA OPPTS 830.7950 (Vapor Pressure)
GLP compliance:
yes (incl. certificate)
Attached in Study report
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Test material information:
Composition 1
Specific details on test material used for the study:
- Batch n°: I15AB0305
- Analytical purity: 99.7%
- Expiry/retest date: 23/01/2017
- Test item storage conditions: At room temperature
Key result
20 °C
Vapour pressure:
< 0 Pa
Key result
25 °C
Vapour pressure:
< 0 Pa

Reference substances

Validation of the method is performed at least once every year (WIL project 512159). Each reference substance was measured in duplicate by TGA using a temperature program that was specific for the substance. Plots of log vT obtained at elevated temperatures and 1/T were inter- or extrapolated to determine the log vTvalues at 20°C (log vT,20). The log vT,20 values were plotted against the logarithm of the vapour pressure at 20°C in Pascal units (log PT,20). Linear regression analysis using the least squares method yielded an equation of log PT,20= 1.34 log vT,20 + 4.96. The coefficient of correlation (r) was > 0.99. The constants c and d specific for the experimental arrangement were 1.34 and 4.96, respectively.


Isothermal TGA analysis: from the plot of the log PT of the test item as a function of the reciprocal temperature the equation of the curve could be derived: log PT= -8622 x 1/T + 18.54 (r = 0.994, n = 8). The calculated vapour pressure of the test item at 20°C and 25°C is:

 Temperature (°C)  log PT  PT (Pa)  PT (mm Hg)
 20  -10.87  1.4 E-11 1.0 E-13
 25  -10.38 4.2 E-11 3.2 E-13

The calculated vapour pressure of the test substance was outside the validated range of the method. Therefore, the vapour pressure of the test item is reported as less than the vapour pressure of the reference substance with the lowest vapour pressure used during the validation of the method. The results for the vapour pressure of the test item at 20°C and 25°C are < 1.3 E-8 and <2.1 E-8 respectively.




The isothermal TGA effusion method was applied for the determination of the vapour pressure of JNJ-42808415-AAA (T003422).
The vapour pressure of the test item was <1.3E-8 Pa (or <1.0E-10 mmHg) at 20°C (293K) and <2.1E-8 Pa (or <1.6E-10 mmHg) at 25°C (298K).

Description of key information

The vapour pressure of T003422 was assessed using the isothermal TGA effusion method, following the guidelines OECD 104, EU method A.4 and EPA OPPTS 830.7950 (K1, Ciric, 2017).

The vapour pressure of the substance was determined to be < 1.3E-8 Pa at 20°C and < 2.1E-8 Pa at 25°C.

Key value for chemical safety assessment

Additional information