Registration Dossier

Physical & Chemical properties

Dissociation constant

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 May 2016 - 09 Sep 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7370 (Dissociation constants in water)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Included in the study report
Test material information:
Composition 1
Specific details on test material used for the study:
- Batch nĀ°: I15AB0305
- Analytical purity: 99.7%
- Expiry/retest date: 23/01/2017
- Test item storage conditions: At room temperature
Dissociating properties:
no
Remarks:
The test item does not contain ionisable groups. No pKa values could be calculated.

The test item does not contain ionisable groups. No pKa values could be calculated

Conclusions:
JNJ-42808415-AAA (T003422) has no pKa values for acidic and basic groups in the logarithm range of 1 ā€“ 14.

Description of key information

The calculation method was applied in a GLP study (K1, Ciric, 2017) as a preliminary test to determine the dissociation constant.

Since the test item does not contain ionisable groups, no pKa could be calculated.

Key value for chemical safety assessment

Additional information