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EC number: 695-878-0 | CAS number: 1283129-18-9
Mutation experiment I:
Toxicity: In strain TA98 (absence of S9-mix), a fluctuation in the number of revertant colonies below the laboratory historical control data range was observed at the lowest dose of 17 μg/plate. However, since no dose-relationship was observed, this reduction is not considered to be caused by toxicity of the test item. This reduction is more likely caused by incidental fluctuations in the number of revertant colonies.
Mutation experiment II:
Toxicity: In strain TA100 (absence of S9-mix), fluctuations in the number of revertant colonies below the laboratory historical control data range were observed at 878 and 2800 μg/plate. However, since no dose-relationship was observed and the reductions in the mean number of revertant colonies were only minor when compared against relevant historical control data, these reductions are caused by incidental fluctuations in the number of revertant colonies and are considered as not biologically relevant.
In strain TA100, a fluctuation in the number of revertant colonies above the laboratory historical control data range was observed in the presence of S9-mix at the mid-dose level of 878 μg/plate. However, since the increase was not two-fold (a maximum of 1.5-fold was reached), this increase was not considered to be relevant.
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