Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
adsorption / desorption
Remarks:
other: adsorption coefficient calculated from the partiton coefficient
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
September 23rd to December 23rd 1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study was conducted according to an OECD Method and in accordance with GLP. The study material is well characterized.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1997

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: Adsorption calculated from the partition coefficient determinded in accordance with OECD 117
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
424-660-8
EC Name:
-
Cas Number:
224631-15-6
Molecular formula:
Hill formula: C18H26N4O5S CAS formula: C18H26N4O5S
IUPAC Name:
(S)-2,5-dioxopyrrolidin-1-yl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate
Radiolabelling:
no

Study design

Batch equilibrium or other method

Analytical monitoring:
yes

Results and discussion

Adsorption coefficient
Type:
Koc
Remarks:
calculated from the partition coefficient results for A-133816.0
Value:
1 585

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The adsorption coeffcient of the components of the test material have been determined to be 1585.


The abiotic hydrolysis for A-133816.0 could not be readily established. The investigations undertaken showed that A-133816.0 could not exist in its ready state in an aquatic environment with complete breakdown of the material to its breakdon products with 1 h (at 20 oC)