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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 Jul - 07 Oct, 1996
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: done under GLP and OECD method

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
84/449/EEC
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
Paris 1981
Qualifier:
according to guideline
Guideline:
other: OJEC L383 A26-47
GLP compliance:
yes
Type of method:
other: Balance method

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
424-660-8
EC Name:
-
Cas Number:
224631-15-6
Molecular formula:
Hill formula: C18H26N4O5S CAS formula: C18H26N4O5S
IUPAC Name:
(S)-2,5-dioxopyrrolidin-1-yl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate

Results and discussion

Vapour pressure
Temp.:
25 °C
Vapour pressure:
0 Pa
Remarks on result:
other: Determined by extrapolation of experimental data

Applicant's summary and conclusion

Conclusions:
Vapour Pressure determined to be 0.000046 Pa at 25°C
Executive summary:

Vapour Pressure determined by balance method to be 4.6 x 10-5 Pa (3.46 x 10 -7 mmHg) by extrapolation of experimental data at 25°C.

The value quoted was determined by the extrapolation of
experimental data to 25°C.  The calculation used a slope of
2000 in the vapour pressure relationship, this being the
shallowest slope observed for around 200 solid compounds.
This value was used because of the inherent difficulty in
extrapolating non-linear data, and provides an estimated
maximum value for the vapour pressure at 25°C.