Registration Dossier
Registration Dossier
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EC number: 944-090-8 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- Adequacy of study:
- weight of evidence
- Study period:
- June 06, 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
Data source
Reference
- Reference Type:
- other: Expert assessment
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance.
- GLP compliance:
- no
- Type of assay:
- other: In vitro mammalian cell micronucleus test, other (not specified)
Test material
- Reference substance name:
- morpholin-4-ium morpholine 6-(4-methylbenzenesulfonamido)hexanoate
- EC Number:
- 944-090-8
- Molecular formula:
- C13H19NO4S.C4H9NO/C4H9NO/H2O
- IUPAC Name:
- morpholin-4-ium morpholine 6-(4-methylbenzenesulfonamido)hexanoate
- Test material form:
- liquid
Constituent 1
Results and discussion
Test results
- Key result
- Remarks on result:
- other: The substance is not expected to induce structural chromosomal aberration in mammalian cells based on the properties of its constituents.
Applicant's summary and conclusion
- Conclusions:
- An assessment was performed based on experimental data and QSAR predictions on the constituents of the substance. Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce structural chromosomal aberration in mammalian cells. It is not considered necessary to carry out further testing.
- Executive summary:
The potential of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) to induce structural chromosomal aberration in mammalian cells is expected to be driven by the capacity of its constituents – 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid, morpholine, and water – to induce structural chromosomal aberration in mammalian cells.
Available data and QSAR predictions on these constituents indicate that they will not induce structural chromosomal aberration in mammalian cells
Based on the activity of its constituents, it is concluded that Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) is not expected to induce structural chromosomal aberration in mammalian cells. It is not considered necessary to carry out further testing.
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