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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From January 06, 2004 to January 08, 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
>= 0.1 - <= 1.5
Temp.:
35 °C
Remarks on result:
other: pH not reported
Type:
log Pow
Partition coefficient:
0.4
Temp.:
35 °C
Remarks on result:
other: pH not reported
Remarks:
calculated weighted average
Details on results:
Calculated average log Kow of 0.4, covering the compounds (peaks) in the chromatogram contributing >/= 5 % to the test substance

Log Kow-values for the test substance Becrosan 2128: Morpholine salt.

Compound / Peak No.  Compound / Peak Retention Time (Min)  Log Kow Area % under Peak
1 1.19 0.1 95
2 1.65 1.5 5
Conclusions:
The partition coefficient (log Pow) of Becrosan 2128: Morpholine salt was determined to be 0.1 to 1.5 at a temperature of 35 ± 1°C. The calculated weighted average, based on log Kow of the distinct compounds / peaks and the area % under the peaks, was calculated to be log Kow = 0.4.
Executive summary:

A study was performed to determine the partition coefficient (log Kow) of Becrosan 2128: Morpholine salt (salt of morpholine and a substituted carboxylic acid) using High Performance Liquid Chromatography (HPLC) according to OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method). No deviation from the guideline was reported and all criteria were met to satisfy test validity. A partition coefficient (log Kow) range of 0.1 to 1.5 was determined for the test substance at a temperature of 35 ± 1°C (OSPAR 1995). Interpreting the single log Kow values and area % beneath the two compounds/peaks acquired from the HPLC chromatogram for Becrosan 2128: Morpholine salt, a Pow of 0.4 was calculated based on the weighted average. As the log Kow range is <3, Becrosan 2128: Morpholine salt cannot be regarded as bioaccumulative.

Description of key information

The partition coefficient (log Pow) of Becrosan 2128: Morpholine salt was determined to be 0.1 to 1.5 at a temperature of 35 ± 1°C. The calculated weighted average, based on log Kow of the distinct compounds/peaks and the area % under the peaks, was calculated to be log Kow = 0.4.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.5
at the temperature of:
35 °C

Additional information