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Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-01-08 to 2018-02-16
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
column elution method
Key result
Water solubility:
28.3 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
7

Table 1: Solubility Results for Compimide 183 at 20 °C

Sample of the Equilibrium

Compimide 183 [mg/L]³

 

at 0.4 mL/min

at 0.2 mL/min

1

29.5

26.8

2

30.0

26.7

3

30.3

26.9

4

29.8

26.6

5

30.5

25.6

Overall [mg/L]

Mean

30.0

26.5

28.3

Deviation [%]

41

51

13²

SD±

0.4

0.5

 

SD = Standard deviation

1) = Calculation according to formula : Deviation = n(cmax- cmin) x 100/cmin

2) = Calculation according to formula: Deviation = |(c1 -c2)| x 100 / c1

3) = Mean value of two injections; for the third sample at 0.2 mL/min, one injection was eliminated as an outlier

Conclusions:
In the present test the water solubility of Compimide 183 was determined to be 28.3 mg/L (20°C, pH 7) using the Column Elution Method.

Description of key information

- study conducted according to OECD guideline 105 (1995), the water solubility of Compimide 183 was determined using the column elution mehtod, the water solubility is considered to be 28.3 mg/L at 20°C.

Key value for chemical safety assessment

Water solubility:
28.3 mg/L
at the temperature of:
20 °C

Additional information