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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2018-01-08
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited
Justification for type of information:
please refer to 'Attached justification'
Guideline:
other: ECHA Guidance R.6
Principles of method if other than guideline:
- Software tool(s) used including version: EPIWIN v4.11
- Model(s) used: BCFBAF v3.01
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
Key result
Type:
BCF
Value:
0.893 L/kg

The prediction does not fall into the applicability domain of this model, since the substance is inorganic.

Conclusions:
The Bioconcentration factor according to Arnot-Gobas method (upper trophic) is log BCF = -0.05 (BCF = 0.893 L/kg bw). However, the prediction does not fall into the applicability domain of this model, since the substance is inorganic.
Executive summary:

The Bioconcentration factor (BCF) was predicted with BCFBAF v3.01 which is implemented in EPIWIN v4.11. The Bioconcentration factor according to Arnot-Gobas method (upper trophic) is log BCF = -0.05 (BCF = 0.893 L/kg bw). However, the prediction does not fall into the applicability domain of this model, since the substance is inorganic.

Description of key information

The Bioconcentration factor (BCF) was predicted with BCFBAF v3.01 which is implemented in EPIWIN v4.11. The Bioconcentration factor according to Arnot-Gobas method (upper trophic) is log BCF = -0.05 (BCF = 0.893 L/kg bw). However, the prediction does not fall into the applicability domain of this model, since the substance is inorganic.

This endpoint is not mandatory for the tonnage band 10 - 100 tpa (REACH Regulation Annex VIII). Data in a WoE approach is only provided in order to better estimate the bioaccumulation potential for the substance (please refer to PBT Assessment).

Key value for chemical safety assessment

BCF (aquatic species):
0.893 L/kg ww

Additional information