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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2016-09-24 - 2017-02-03
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
Department of Health of the Government of the United Kingdom
Type of method:
effusion method: vapour pressure balance
Key result
Temp.:
25 °C
Vapour pressure:
0.036 Pa
Temp.:
40 °C
Vapour pressure:
0.091 Pa
Temp.:
70 °C
Vapour pressure:
0.608 Pa

Preliminary Run

The recorded temperatures and the calculated vapor pressure values for the preliminary run are shown in the following table:

Table 2: Preliminary Run Vapor Pressure Data

Temperature

(°C)

Temperature

(K)

Vapor

Pressure

(Pa)

Temperature

(°C)

Temperature

(K)

Vapor

Pressure

(Pa)

20 293,15 0,028625843 46 319,15 0,111407560
21 294,15 0,027237587 47 320,15 0,118876378
22 295,15 0,027681829 48 321,15 0,127025442
23 296,15 0,028986789 49 322,15 0,138145374
24 297,15 0,030250103 50 323,15 0,144711826
25 298,15 0,031999305 51 324,15 0,155193160
26 299,15 0,033082145 52 325,15 0,165743908
27 300,15 0,035539359 53 326,15 0,178432569
28 301,15 0,035705949 54 327,15 0,191648768
29 302,15 0,039384828 55 328,15 0,205947807
30 303,15 0,041147914 56 329,15 0,217859045
31 304,15 0,042813821 57 330,15 0,216082077
32 305,15 0,045298800 58 331,15 0,233449162
33 306,15 0,048741675 59 332,15 0,245874055
34 307,15 0,052267846 60 333,15 0,267225436
35 308,15 0,055252597 61 334,15 0,282954378
36 309,15 0,059889372 62 335,15 0,300710175
37 310,15 0,061916226 63 336,15 0,323408164
38 311,15 0,065956052 64 337,15 0,346120035
39 312,15 0,071273073 65 338,15 0,366541284
40 313,15 0,074715949 66 339,15 0,397749283
41 314,15 0,079213899 67 340,15 0,429581998
42 315,15 0,087501788 68 341,15 0,454848261
43 316,15 0,092180212 69 342,15 0,489804552
44 317,15 0,099440792 70 343,15 0,527329117
45 318,15 0,105146524  

Definitive Runs

The direct values of the vapor pressure at 25 °C are shown in the following table:

Table 3: Vapor Pressure Data at 25 °C

Run Mass Difference (μg)

Vapor

Pressure (Pa)

1 31,60 0,043868896
2 29,29 0,040662024
3 28,67 0,039801305
4 26,93 0,037385739
5 26,15 0,036302900
6 25,80 0,035817010
7 24,74 0,034345458
8 24,15 0,033526387
9 23,46 0,032568490
10 22,46 0,031180234

Mean vapor pressure at 25 °C: 0.0365 Pa

The test item did not change in appearance during the determination.

The direct values of the vapor pressure at 40 °C are shown in the following table:

Table 4: Vapor Pressure Data at 40 °C

Run

Mass

Difference (μg)

Vapor

Pressure (Pa)

1 79,42 0,110255307
2 72,68 0,100898461
3 71,33 0,099024315
4 66,95 0,092943752
5 66,43 0,092221859
6 63,79 0,088556863
7 62,15 0,086280123
8 60,16 0,083517493
9 58,06 0,080602155
10 57,94 0,080435564

Mean vapor pressure at 40 °C: 0.00915 Pa

The test item did not change in appearance during the determination.

The direct values of the vapor pressure at 70 °C are shown in the following table:

Table 5: Vapor Pressure Data at 70 °C

Run Mass Difference (μg) Vapor Pressure (Pa)
1 469,70 0,652063936
2 465,51 0,646247143
3 449,58 0,624132222
4 441,42 0,612804051
5 436,98 0,606640194
6 425,07 0,590106062
7 428,33 0,594631778
8 421,42 0,585038927
9 421,49 0,585136105
10 420,08 0,583178664

Mean vapor pressure at 70 °C: 0.608 Pa

Conclusion

The vapor pressure of the test item has been determined at three temperatures and the results are shown in the following table:

Temperature (°C) Temperature (K) Vapor Pressure (Pa)
25 298 3.65X10-2
40 313 9.15X10-2
70 343 0,608
Conclusions:
The vapor pressure of the test item has been determined at three temperatures and the results are as follows:

25 °C 298 K 3.65X10-2 Pa
40°C 313 K 9.15X10-2 Pa
70°C 343 K 0,608 Pa
Executive summary:

The vapor pressure of the test item has been determined at three temperatures using the vapor pressure balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

The vapor pressure of the test item has been determined at three temperatures and the results are as follows:

25 °C       298 K       3.65X10-2 Pa

40°C       313 K       9.15X10-2 Pa

70°C       343 K       0,608 Pa

Description of key information

Method A.4 Vapour Pressure: 0.0365 Pa at 25 °C, 0.0915 Pa at 40 °C, 0.608 Pa at 70 °C

Key value for chemical safety assessment

Vapour pressure:
0.036 Pa
at the temperature of:
25 °C

Additional information

The vapor pressure of the test item has been determined at three temperatures using the vapor pressure balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

The vapor pressure of the test item has been determined at three temperatures and the results are as follows:

25 °C       298 K       3.65X10-2 Pa

40°C       313 K       9.15X10-2 Pa

70°C       343 K       0,608 Pa