Registration Dossier

Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient in regard to product specification

Data source

Reference
Reference Type:
publication
Title:
Bedeutung von Rueckstaenden von Textilwaschmitteln aus dermato-toxikologischer Sicht
Author:
Matthies W, Loehr A and Ippen H
Year:
1990
Bibliographic source:
Dermatosen 38, 184-189

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
commercial detergents

Method

Route of administration:
dermal

Results and discussion

Results of examinations:
Exp. 1: All subjects tolerated the washed patches without any skin reaction.
Exp. 2: Neither was a case of a skin reaction seen, nor did the children complain any unpleasant skin sensations.

Any other information on results incl. tables

These experiments lead to the conclusion, that amounts of Zeolite A leaving on clothes do not pose a risk for skin irritation for consumers even for the sensitive skin of children. As a calculation of the amount of sodium aluminium silicate (Zeolite A) to be found as residue on textile the value must be theoretically lower than the reported 25000 ppm, therefore these results cannot be used for exposure estimation.

Applicant's summary and conclusion