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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report Date:
1986

Materials and methods

Principles of method if other than guideline:
Animals were exposed to dust at room temperature for 4 hours. Post-observation period was 14 days. All animals were necropsied.
GLP compliance:
not specified
Test type:
other: acute inhalation test
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Molecular Sieve Type ZLD 4040
- Chemical name: Zeolite, cuboidal, crystalline, synthetic, non-fibrous
- Framework: cuboidal
- Related CAS number: 1318-02-1
- Substance type: white powder
- Analytical purity: no data
- Lot/batch No.: Lot 12217-11/ charge 13-131-000824-160-32380-00

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
other: air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: plexiglass chamber
- Exposure chamber volume: 120 L
- System of generating dust: Airborne dust is generated by a baffled Wright Dust Feed through which air is passed at 30 L/min and 5psi. The dust is directly deliverd to the exposure chamber containing the test animals.
- Temperature, humidity, pressure in air chamber: room temperature


TEST ATMOSPHERE
- Brief description of analytical method used: Airborne dust concentrations are measured gravimetrically approx. every 30 min. The mass median aerodynamic diameter is measured by means of a Sierra Cascade Impactor with 8 stages of glass fiber filters.
- Samples taken from breathing zone: yes


TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: Approx. 76% of the particles (by weight) were 10 µm or less in diameter
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 4.2 µm/ 3.45
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
mean analytical concentration was 3.35 mg/L
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 3.35 mg/L air (analytical)
Exp. duration:
4 h

Any other information on results incl. tables

Four hours of exposure resulted in no deaths among all test animals. There were no signs of toxicity during or following exposure. No unusual gross pathology was evident at necropsy.

Applicant's summary and conclusion