Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.031 µg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.31 µg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.003 µg/L
Assessment factor:
10 000
Extrapolation method:
assessment factor
PNEC marine water (intermittent releases):
0.031 µg/L

STP

Hazard assessment conclusion:
no emission to STP expected

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
12.9 µg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
1.29 µg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
2.55 µg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

Conclusive experimental results are available from acute tests for fish and invertebrates (daphnia).

Additionally for algae information obtained from ECOSAR calculation is available.

 

Fish: 96-h-LC50: 0.768 mg/l nominal (97. 8% a.i)

Daphnia: 48h-EC50: 2.18 mg/l nominal (97.8 % a.i.)

Algae: EC50 (96h): 0.031 mg/l (ECOSAR)

Not readily biodegradable

Log Kow: 3.83.

 

Evaluation is based on classification categories for hazardous to the aquatic environment according to GHS Regulation EC No 1272/2008.

The following criteria are relevant for Caprinoguanamine:

 

Acute (short-term) aquatic hazard:

Category Acute 1:

96 hr LC50 (for fish)                           ≤ 1 mg/l and/or

48 hr EC50 (for crustacea)                  ≤ 1 mg/l and/or

72 or 96 hr ErC50 (for algae)              ≤ 1 mg/l

 

Long-term aquatic hazard

(iii) Substances for which adequate chronic toxicity data are not available

Category Chronic 1:

96 hr LC50 (for fish)                         ≤ 1 mg/l and/or

48 hr EC50 (for crustacea)                ≤ 1 mg/l and/or

72 or 96 hr ErC50 (for algae)             ≤ 1 mg/l

 

and the substance is not rapidly degradable and/or the experimentally determined BCF ≥ 500 (or, if absent, the log Kow ≥ 4).


The acute EC50/LC50 values are below the cut off value for classification of ≤ 1 mg/L for acute aquatic hazard. Long term aquatic toxicity of substances for which adequate chronic toxicity data are not available is assessed based on acute EC50/LC50 values.

For both acute and long-term toxicity the cut off value of ≤ 1 mg/L is relevant as the lowest acute effect level was determined to be 0.031 mg/l for algae.

 

Therefore Caprinoguanamine has to be classified for environmental hazard Aquatic Acute Category 1 and Aquatic Chronic Category 1, labelling with H400 and H410 is required, respectively.

 

For classification in Acute Category 1 and Chronic Category 1 the indication of an M-factor is necessary.

The lowest EC50 value is 0.031 mg/L, therefore the appropriate M-factor is 10 (0.01 < L(E)C50 ≤ 0.1).