Registration Dossier
Registration Dossier
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EC number: 227-645-2 | CAS number: 5921-65-3
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-03-30 to 2016-04-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 3.83
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not determined
- Conclusions:
- Caprinoguanamine eluted with a retention time of 10.14 min and the log Pow value of Caprinoguanamine was determined to be 3.83 based on the results of HPLC determination.
- Executive summary:
The aim of this study was the determination of the n-octanol/water partition coefficient of the test item Caprinoguanamine by high performance liquid chromatography (HPLC) method according to EC method A.8 and OECD guideline 117.
The analysis was performed on an analytical column packed with a solid phase containing long hydrocarbon chains chemically bound onto silica (Luna 51J C18(2) 100A, 250 x 3.0 mm). A methanol/water (75/25) mixture was used as mobile phase and the column temperature was 20 ± 1 °C.
Caprinoguanamine eluted with a retention time of 10.14 min and the log Pow value of Caprinoguanamine was determined to be 3.83 based on the results of HPLC determination.
Reference
Description of key information
The log Pow value of Caprinoguanamine was determined to be 3.83 based on the results of HPLC determination.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.83
- at the temperature of:
- 20 °C
Additional information
The aim of this study was the determination of the n-octanol/water partition coefficient of the test item Caprinoguanamine by high performance liquid chromatography (HPLC) method according to EC method A.8 and OECD guideline 117.
The analysis was performed on an analytical column packed with a solid phase containing long hydrocarbon chains chemically bound onto silica (Luna 51J C18(2) 100A, 250 x 3.0 mm). A methanol/water (75/25) mixture was used as mobile phase and the column temperature was 20 ± 1 °C.
Caprinoguanamine eluted with a retention time of 10.14 min and the log Pow value of Caprinoguanamine was determined to be 3.83 based on the results of HPLC determination.
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