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EC number: 608-727-0 | CAS number: 323178-01-4
Skin irritation: OECD 404: negative
Eye irritation: Read Across from OECD 405 of structural analogues = negative
To test for primary skin irritation, 0.5g of the test material was mixed with some drops of liquid paraffin to ensure good contact to the skin. Afterwards, the test material was spread onto 6 cm2 patches and applied to the intact skin of previously shaven rabbits for a 4 hours period under semiocclusive conditions.
According to the result of a pre-test, the animal study was started with three animals.
The first examination of the treated skin sites followed 1 hour after removal of the patches. Then examinations were performed daily for further 7 days.
Under the conditions of the present study, no signs of irritation were seen.
Body weight development of the treated rabbits was inconspicuous.
No skin irritating potential could be detected.
This study was performed according to GLP and methods applied are fully compliant with OECD TG 404. For the test item no irritating potential could be detected.
For this endpoint two one-to-one read across options were performed to chemical similar compounds of the same chemical class with a comparable phys. chem. profile and similar responses in biological assays. The relevant studies were performed according to GLP and the methods applied are fully compliant with OECD TG 405. The data demonstrate absence of eye irritation potential for this class of compounds.
To test for primary eye irritation, the test material was instilled into the conjunctival say of rabbits. The first examination of the treated eye followed 1 hour after instillation. The examinations were performed daily for further 7 days.
In the primary eye irritation test, no abnormalities of the cornea and iris were observed. The conjunctivae showed redness (score 1) in all animals at 24h. Later on no abnormalities were seen.
According to these results, for regulatory purposes the test material has to be classified as non-irritant for the eyes.
The study was performed according to OECD 405 under GLP conditions. According to these results, for regulatory purposes there is no need for classification for eye irritation.
The test material was tested for its eye irritating properties. Prior to testing, the hen's egg test on the chorioallantoic membrane was performed and no irritating potential could be detected. The test for primary eye irritation was performed initially with one animal and followed by the confirmatory test with two further animals.For the test of primary eye irritation, the test material was applied into the conjunctival sac of rabbits. The first examination of the eyes followed 1 hour after instillation. The other examinations of the eyes were performed daily for a further 7 days.
No signs of irritation were observed at the cornea or iris. All animals showed discharge (score 1) one hour after instillation of the test material. In two animals redness (score 1) was observed one hour after treatment. No abnormalities were detected in the untreated eyes.
No relevant eye irritating potential could be detected. The test material should not be classified as an eye irritant.
The study was performed according to OECD 405 under GLP conditions. No relevant eye irritating potential could be detected. The test material should not be classified as an eye irritant.
Based on the provided information there is no need for classification according to the EU Regulation (EC) No 1272/2008 on Classification,Labelling and Packaging of Substances and Mixtures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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