Registration Dossier
Registration Dossier
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EC number: 274-092-8 | CAS number: 69709-01-9
Endpoint summary
Administrative data
Description of key information
1,1,3,3-Tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine is a liquid at standard temperature and pressure, with a measured melting point of <-80°C and it has a predicted density of 1.02 g/cm3 at 20°C. The substance is observed to undergo thermal decomposition from >150°C. It has a predicted vapour pressure of 9.9E-02 Pa at 25°C.
The substance is not classified for flammability according to Regulation (EC) No. 1272/2008 on the basis of a measured flash point of 124°C. It has a measured auto-ignition temperature of 289°C, and is not oxidising on the basis of structural examination. 1,1,3,3-Tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine was found not to exhibit explosivity hazard under the conditions of an EU Method A.14 test.
In contact with water, the substance hydrolyses rapidly resulting in the formation of 1,1,3,3-tetramethyl-2-[3-(trihydroxysilyl)propyl]guanidine and methanol according to the following equation:
C11H27N3O3Si + 3H2O → C8H21N3O3Si + 3CH3OH
The properties of the substance have been estimated using appropriate QSAR methods. The unionised form of the substance has a predicted log Kow of 1.2. In solution, the amine group will protonate and the substance will exist only in the ionised form in the environment and in vivo; therefore, the estimated log Kow was corrected for ionisation using the equation provided in the ECHA Guidance R.7a (2008). Log Kow values of -4, -4, -4 and -2.3 at pH 2, pH 4, pH 7 and pH 9 respectively were determined. 1,1,3,3-Tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine has a predicted water solubility value of 3.7E+05 mg/l at 20°C.
Methanol is miscible with water, has low log Kow (-0.82 to -0.64) and high vapour pressure (12790 Pa at 20°C) (OECD, 2004a: SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18 - 20 October 2004, Methanol, CAS 67-56-1).
The saturation concentration in water of the silanol hydrolysis product, 1,1,3,3-tetramethyl-2-[3-(trihydroxysilyl)propyl]guanidine, is limited by condensation reactions to approximately 1000 mg/l. However, it is very hydrophilic (calculated solubility is 1.0E+06 mg/l using a QSAR method) and the ionised form of the silanol hydrolysis product have predicted log Kow of -4 at pH 2, pH 4, pH 7 and pH 9. 1,1,3,3-Tetramethyl-2-[3-(trihydroxysilyl)propyl]guanidine is not surface active and is much less volatile than the parent substance (vapour pressure = 1.6E-06 Pa at 25°C predicted).
Additional information
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