Registration Dossier
Registration Dossier
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EC number: 274-092-8 | CAS number: 69709-01-9
Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study, conducted according to a protocol similar to OECD TG 401, but not compliant with GLP, the reported LD50 value for 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine was 3.67 mL/kg bw, equivalent to 3743 mg/kg bw (Shin-Etsu, 1983).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 743 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the key acute oral toxicity study, conducted according to a protocol similar to OECD TG 401, but not compliant with GLP, the reported LD50 value for 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine was 3.67 mL/kg bw (Shin-Etsu, 1983). Assuming a density of 1.02 gm/cm3, this is equivalent to 3743 mg/kg bw.
Following oral administration of 2.07, 2.49, 2.99, 3.58 or 4.30 mL/kg bw of undiluted test material to 5 males and 5 females per dose, sedation, rough coats and signs of unconsciousness during the first 4 hours post-administration were observed. Mortalities were evident in males treated with 2.99, 3.58 and 4.30 ml/kg bw, and females treated with 3.58 and 4.30 ml/kg bw. Deaths occurred between 3 and 21 hours post-administration. The survivors recovered gradually and looked healthy by the end of the study. No changes in body weight gain were noted, as well as no treatment-related macroscopic abnormalities at necropsy.
Justification for classification or non-classification
Based on the available data, 1,1,3,3-tetramethyl-2-[3-(trimethoxysilyl)propyl]guanidine is not classified for acute toxicity according to Regulation (EC) No. 1272/2008.
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