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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-06-27 to 2017-08-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: Knudsen cell
Key result
Temp.:
20 °C
Vapour pressure:
467.93 Pa
Temp.:
25 °C
Vapour pressure:
717.15 Pa

Two series of vapour pressure measurement were performed in temperature range 22 to 27 °C and these data were used for evaluation. The measured vapour pressure data and the corresponding measured temperatures are shown in Table 1 and 2.

Table 1: Results of the Effusion method (Series 1)

Stage No. Temperature (°C) Δm/Δt (mg/min) Vapour pressure (Pa)
1 21.8 1.9137 549.42
2 23.0 2.2809 656.23
3 24.2 2.2419 646.25
4 25.2 2.5167 726.70
5 25.5 2.5960 749.97
6 26.4 2.8928 836.98
Extrapolated
values:
20.00   478.55
25.00   725.90

Table 2: Results of Effusion method (Series 2)

Stage No.

Temperature

(°C)

Δm/Δt (mg/min)

Vapour pressure

(Pa)

1 21.8 1.9080 547.79
2 23.0 2.0058 577.02
3 23.9 2.2364 644.33
4 25.0 2.5094 724.39
5 26.0 2.6150 756.13
6 26.8 2.8977 838.92
Extrapolated
values:
20.00   457.31
25.00   708.40
Conclusions:
The vapour pressure values of the test item for temperatures 20 and 25 °C was calculated by the means of the extrapolated vapour pressure values of the two series:
Vapour pressure at 20 °C: 467.93 Pa
Vapour pressure at 25 °C: 717.15 Pa
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item by using the effusion method (Knudsen cell). According to several publications the boiling point of the test item was stated to be in the range of 145 and 152 °C. Two series of vapour pressure measurement were performed at temperatures between 22 and 27 °C (6 stages). The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C. The vapour pressure was calculated to be 467.93 Pa at 20 °C and 717.15 Pa at 25 °C, respectively.

Description of key information

The vapour pressure values of the test item for temperatures 20 and 25 °C was calculated by the means of the extrapolated vapour pressure values of the two series:

Vapour pressure at 20 °C: 467.93 Pa

Vapour pressure at 25 °C: 717.15 Pa

Key value for chemical safety assessment

Vapour pressure:
467.93 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item by using the effusion method (Knudsen cell). According to several publications the boiling point of the test item was stated to be in the range of 145 and 152 °C. Two series of vapour pressure measurement were performed at temperatures between 22 and 27 °C (6 stages). The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C. The vapour pressure was calculated to be 467.93 Pa at 20 °C and 717.15 Pa at 25 °C, respectively (reference 4.6-1).