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EC number: 229-227-5 | CAS number: 6441-82-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SIDS INITIAL ASSESSMENT PROFILE for 3-Chloropropyl)triethoxysilane (CPTES) CAS No. 5089-70-3
- Author:
- United Nations Environmental Programme (UNEP)
- Year:
- 2 010
- Bibliographic source:
- SIDS INITIAL ASSESSMENT PROFILE for 3-Chloropropyl)triethoxysilane (CPTES), United Nations Environmental Programme (UNEP), 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of 3-Chloropropyl)triethoxysilane (CAS No. 5089-70-3) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- (3-chloropropyl)triethoxysilane
- Cas Number:
- 5089-70-3
- Molecular formula:
- C9H21ClO3Si
- IUPAC Name:
- (3-chloropropyl)triethoxysilane
- Details on test material:
- Name: (3-chloropropyl)triethoxysilane
Smiles - ClCCC[Si](OCC)(OCC)OCC
InChI - 1S/C9H21ClO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-9H2,1-3H3
- Molecular formula (if other than submission substance):C9H21ClO3Si
- Molecular weight (if other than submission substance):240.801 g/mole
- Substance type:organic
Constituent 1
- Specific details on test material used for the study:
- Name: (3-chloropropyl)triethoxysilane
Smiles - ClCCC[Si](OCC)(OCC)OCC
InChI - 1S/C9H21ClO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-9H2,1-3H3
- Molecular formula (if other than submission substance):C9H21ClO3Si
- Molecular weight (if other than submission substance):240.801 g/mole
- Substance type:organic
- Purity97.0%
- Impurities (identity and concentrations):3.0%
Test animals
- Species:
- rat
- Strain:
- other: WISW (SPF-Crb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: semi-occlusive dressing to the dorsal skin
- % coverage: The test substance application volume was 2.00 cm3/kg body weight.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The test substance application removed with warm water after the 24 hour exposure period. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- Total = 10
5 male and 5 female - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were examined for clinical signs 30 minutes, 1, 2, 3, 4, 5, and 6 hrs post-dosing, and then once daily for two weeks. Body weight determinations were performed on the day of dosing, and days 7 and 14 (study termination).
- Necropsy of survivors performed: yes
- Other examinations performed: All animals were observed for clinical signs. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No Mortality observed
- Mortality:
- No Mortality observed at 2000 mg/kg
- Clinical signs:
- other: No signs of toxicity were observed in rats. Very slight erythema was observed in one male animal (48 and 72 hours after application) and two female animals (48 hours to day 5) at the site of application. By day 6, all skin irritation had subsided. No abno
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 was considered to be >2000 mg/kg bw, when male and female rats were treated with of 3-Chloropropyl)triethoxysilane (CAS No. 5089-70-3) by semi-occlusive dermal application.
- Executive summary:
Acute Dermal toxicity study was conducted in male and female rats using 3-Chloropropyl)triethoxysilane (CAS No. 5089-70-3) at the concentration of 2000 mg/kg bw. Test material (purity - 97.0%) was applied undiluted at 2000 mg/kg for 24 hours under a semi-occlusive dressing to the dorsal skin of 5 male and 5 female rats. The application volume was 2.00 cm3/kg body weight. The test substance was removed with warm water after the 24 hour exposure period. The animals were examined for clinical signs 30 minutes, 1, 2, 3, 4, 5, and 6 hrs post-dosing, and then once daily for two weeks. Body weight determinations were performed on the day of dosing, and days 7 and 14 (study termination). All animals were subject to a gross necropsy. The test substance with an applied dose of 2000 mg/kg body weight in 5 male and 5 female animals caused no lethality. Normal body weight gain was observed during the 14-day observation period. No signs of toxicity were observed in the male or female animals. Very slight erythema was observed in one male animal (48 and 72 hours after application) and two female animals (48 hours to day 5) at the site of application. By day 6, all skin irritation had subsided. No abnormalities were noted at necropsy. Therefore, LD50 was considered to be >2000 mg/kg bw, when male and female rats were treated with of 3-Chloropropyl)triethoxysilane by semi-occlusive dermal application.
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