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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
SIDS INITIAL ASSESSMENT PROFILE for 3-Chloropropyl)triethoxysilane (CPTES) CAS No. 5089-70-3
Author:
United Nations Environmental Programme (UNEP)
Year:
2010
Bibliographic source:
SIDS INITIAL ASSESSMENT PROFILE for 3-Chloropropyl)triethoxysilane (CPTES), United Nations Environmental Programme (UNEP), 2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute dermal toxicity study of 3-Chloropropyl)triethoxysilane (CAS No. 5089-70-3) in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name: (3-chloropropyl)triethoxysilane
Smiles - ClCCC[Si](OCC)(OCC)OCC
InChI - 1S/C9H21ClO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-9H2,1-3H3
- Molecular formula (if other than submission substance):C9H21ClO3Si
- Molecular weight (if other than submission substance):240.801 g/mole
- Substance type:organic
Specific details on test material used for the study:
Name: (3-chloropropyl)triethoxysilane
Smiles - ClCCC[Si](OCC)(OCC)OCC
InChI - 1S/C9H21ClO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-9H2,1-3H3
- Molecular formula (if other than submission substance):C9H21ClO3Si
- Molecular weight (if other than submission substance):240.801 g/mole
- Substance type:organic
- Purity97.0%
- Impurities (identity and concentrations):3.0%

Test animals

Species:
rat
Strain:
other: WISW (SPF-Crb)
Sex:
male/female
Details on test animals and environmental conditions:
not specified

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: semi-occlusive dressing to the dorsal skin
- % coverage: The test substance application volume was 2.00 cm3/kg body weight.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The test substance application removed with warm water after the 24 hour exposure period.
Duration of exposure:
24 hours
Doses:
2000 mg/kg
No. of animals per sex per dose:
Total = 10
5 male and 5 female
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were examined for clinical signs 30 minutes, 1, 2, 3, 4, 5, and 6 hrs post-dosing, and then once daily for two weeks. Body weight determinations were performed on the day of dosing, and days 7 and 14 (study termination).
- Necropsy of survivors performed: yes
- Other examinations performed: All animals were observed for clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No Mortality observed
Mortality:
No Mortality observed at 2000 mg/kg
Clinical signs:
No signs of toxicity were observed in rats. Very slight erythema was observed in one male animal (48 and 72 hours after application) and two female animals (48 hours to day 5) at the site of application. By day 6, all skin irritation had subsided. No abnormalities were noted at necropsy.
Body weight:
Normal bodyweight gain was observed during the 14-day observation period.
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 was considered to be >2000 mg/kg bw, when male and female rats were treated with of 3-Chloropropyl)triethoxysilane (CAS No. 5089-70-3) by semi-occlusive dermal application.
Executive summary:

Acute Dermal toxicity study was conducted in male and female rats using 3-Chloropropyl)triethoxysilane (CAS No. 5089-70-3) at the concentration of 2000 mg/kg bw. Test material (purity - 97.0%) was applied undiluted at 2000 mg/kg for 24 hours under a semi-occlusive dressing to the dorsal skin of 5 male and 5 female rats. The application volume was 2.00 cm3/kg body weight. The test substance was removed with warm water after the 24 hour exposure period. The animals were examined for clinical signs 30 minutes, 1, 2, 3, 4, 5, and 6 hrs post-dosing, and then once daily for two weeks. Body weight determinations were performed on the day of dosing, and days 7 and 14 (study termination). All animals were subject to a gross necropsy. The test substance with an applied dose of 2000 mg/kg body weight in 5 male and 5 female animals caused no lethality. Normal body weight gain was observed during the 14-day observation period. No signs of toxicity were observed in the male or female animals. Very slight erythema was observed in one male animal (48 and 72 hours after application) and two female animals (48 hours to day 5) at the site of application. By day 6, all skin irritation had subsided. No abnormalities were noted at necropsy. Therefore, LD50 was considered to be >2000 mg/kg bw, when male and female rats were treated with of 3-Chloropropyl)triethoxysilane by semi-occlusive dermal application.