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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of 2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride (CAS no: 3648-36-0) in Rat.
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute oral toxicity of 2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride (CAS no: 3648-36-0) in Rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name - 2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride
InChI -1S/C22H26ClN2.ClH/c1-22(2)19-7-5-6-8-20(19)25(4)21(22)14-11-17-9-12-18(13-10-17)24(3)16-15-23;/h5-14H,15-16H2,1-4H3;1H/q+1;/p-1
Smiles -c12c([N+](C)=C(C1(C)C)\C=C\c1ccc(N(CCCl)C)cc1)cccc2.[ClH-]
- Molecular formula (if other than submission substance):C22H26Cl2N2
- Molecular weight (if other than submission substance):389.367 g/mole
- Substance type:Organic
Specific details on test material used for the study:
Name - 2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride
InChI -1S/C22H26ClN2.ClH/c1-22(2)19-7-5-6-8-20(19)25(4)21(22)14-11-17-9-12-18(13-10-17)24(3)16-15-23;/h5-14H,15-16H2,1-4H3;1H/q+1;/p-1
Smiles -c12c([N+](C)=C(C1(C)C)\C=C\c1ccc(N(CCCl)C)cc1)cccc2.[ClH-]
- Molecular formula (if other than submission substance):C22H26Cl2N2
- Molecular weight (if other than submission substance):389.367 g/mole
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
2260 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 260 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 2260 mg/kg bw
Clinical signs:
Changes in Blood were observed in tested animals.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 was considered to be 2260 mg/kg bw, when rats were treated with 2-[2-[4-[(2-chloroethyl)methylamino]phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride (CAS no: 3648-36-0) via oral route.
Executive summary:

The acute oral toxicity of 2-[2-[4-[(2-chloroethyl)methylamino] phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride (CAS no: 3648-36-0) was tested inrat at the dose concentration of 2260 mg/kg bw. Changes in Blood were observed in tested animals. 50% mortality was observed at 2260 mg/kg bw. Therefore, LD50 was considered to be 2260 mg/kg bw, when rats were treated with 2-[2-[4-[(2-chloroethyl)methylamino] phenyl]vinyl]-1,3,3-trimethyl-3H-indolium chloride (CAS no: 3648-36-0) via oral route.