Registration Dossier

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary source .

Data source

Reference
Reference Type:
secondary source
Title:
Determination of skin sensitization for 91-68-9
Author:
IUCLI D ATASET
Year:
2000
Bibliographic source:
EUROPEAN COMMISSION – European Chemicals Bureau

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Skin sensitization study of 3–diethylaminophenol was conducted in guinea pigs to determine its sensitization efficacy.
GLP compliance:
not specified
Type of study:
skin painting test
Justification for non-LLNA method:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Test material form:
not specified
Details on test material:
Details on test material
- Name of test material (as cited in study report):
- Molecular formula: C10H15NO
- Molecular weight: 165.234g/mol
- Substance type: Organic
Specific details on test material used for the study:
Details on test material
- Name of test material (as cited in study report): 3–diethylaminophenol
- Molecular formula (if other than submission substance): C10H15NO
- Molecular weight (if other than submission substance): 165.234g/mol
- Substance type: Organic

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available.

Study design: in vivo (non-LLNA)

Induction
Route:
other: No data
Vehicle:
no data
Concentration / amount:
No data available
Challenge
Route:
other: No data
Vehicle:
no data
Concentration / amount:
No data available
No. of animals per dose:
No data available.
Details on study design:
No data available.

Study design: in vivo (LLNA)

Statistics:
No data available.

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test group
No. with + reactions:
0
Clinical observations:
not sensitizing
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: not sensitising
Conclusions:
The test material 3–diethylaminophenol (CAS No: 91-68-9) was observed to be non sensitizing to guinea pigs.
Executive summary:

The skin sensitization study of 3–diethylaminophenol(CAS No: 91-68-9)was performed in guinea pigs to observed its sensitizing potential.The guinea pigs did not produce any sensitization potential .Thus3–diethylaminophenolwas considered to be non sensitizing to the guinea pigs.