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EC number: 202-461-5 | CAS number: 95-87-4
LD50-values (mg/kg bw ± standard error if indicated)
383 ± 36
444 ± 26
The acute toxicity of 4 solid, crystalline xylenol isomers including 2,5-xylenol was studied in white mice, albino rats, and rabbits in accordance with international accepted scientific methods. No guideline was followed. A single dose of the substances was administered by mouth in the form of finely dispersed aqueous suspensions. The animals were kept under clinical observation for 15 days. Data on rat and mice mortality were processed statistically by probit analysis as modified by Prozorovsky (1962). LD50 for rabbits was determined by the method of Deichmann and Le Blanc (1943). The clinical picture was similar in all the species of laboratory animals investigated (and for all the isomers considered). The clinical signs of acute poisoning were dyspnea, disturbance of motor coordination, a rapid advent of clonic spasms, and an asymmetrical body position. Most of the animals with acute poisoning died within 24 hours of administration.
Based on the study results, LD50values of 383 ±36 (S.E.), 444 ± 26, and 938 mg/kg bw were calculated for white mice, albino rats and rabbits, respectively.
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