3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene

Endpoint summary

Additional information

Experimental studies investigating the short-term toxicity of 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene (CAS 25291-17-2) to aquatic organisms are available. All studies were performed under GLP conditions according to standard OECD guidelines. Due to the high vapour pressure of the substance (4640 Pa at 25 °C) it was ensured during preparation of test solutions and during exposure that the substance does not evaporate from the test medium by avoiding any headspace. No effects were recorded in any of the available studies up to the maximum concentration of 100 mg/L (nominal) resulting in EC50 values of > 100 mg/L. The NOEC in the algae study was derived to be ≥ 100 mg/L. In all studies the exposure concentrations were verified by GC/MS analysis to be in the range of 0.0139 - 0.117 mg/L (geometric mean) reflecting the low water solubility of the test item. In conclusion no effects of the substance were recorded by testing a saturated solution.
Testing for inhibition of respiration of activated sludge microorganisms is generally performed in open systems according to OECD 209. Due to the high volatility of the substance it was not possible to maintain test concentrations in the test medium as investigated in a pre-test with a shorter test duration of 30 min instead of 3 h. Thus, it was considered that it is technically not possible to adequately perform a full study due to significant loss of test substance. During this pre-test no inhibition of respiration was measured. Therefore, it is not anticipated that the test item inhibits the degradation process in sewage treatment plants. Evaporation is considered to be a substance-specific process of elimination in sewage treatment plants as well.