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EC number: 246-791-8 | CAS number: 25291-17-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 Feb - 01 Mar 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP Guideline Study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: "Method for testing the biodegradability of chemical substances by microorganisms" stipulated in the "Testing methods for new chemical substances" (November 21, 2003; No. 1121002, Pharmaceutical and food safety bureau)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Details on inoculum:
- - Source of inoculum/activated sludge: The inoculum consists of sewage sludge, surface water and surface soil which was in contact with the atmosphere. Sampling locations were: Fushikogawa city sewage treatment plant, Fukashiba industrial sewage plant, Nakahama city sewage plant, Ochiai city sewage plant, Kitakami river, Shinano river, Yoshino river, Lake Biwa, Hiroshima bay, Dokai bay. All samples were taken in December 2006.
- Laboratory culture: no
- Method of cultivation: Activated sludge was prepared by mixing a filtrate of the supernatant of the sludge collected at sampling sites with the filtrate of the supernatant of the activated sludge previously cultivated for about three months. The mixed filtrate was aerated after the pH was adjusted to 7.0 ± 1.0. After ceasing aeration of the sludge mixture for approx. 30 min, supernatant corresponding to about one third of the whole volume was removed. Dechlorinated water was added to the remaining portion so that the total volume was 10 L. This mixture was aerated for 30 min or more, and then a predetermined amount of synthetic sewage was added to the mixture so that the concentration of the synthetic sewage was 0.1% in the volume of dechlorinated water added. Cultivation was carried out at 25 ± 2 °C. The activated sludge, which was cultivated for 18.5 h after it was added to the synthetic sewage was used.
- Suspended solids concentration: 30 mg/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guideline
- Test temperature: 25 ± 1 °C
- Suspended solids concentration: 30 mg/L
- Continuous darkness: yes
- Other: All test solutions were stirred with a magnetic stirrer.
TEST SYSTEM
- Culturing apparatus: Closed system oxygen consumption measuring apparatus (volume: 300 mL)
- Number of culture flasks/concentration: 3 bottles
- Measuring equipment: The BOD was measured automatically with a closed system oxygen consumption measuring apparatus.
- Test performed in closed vessels due to significant volatility of test substance: yes
- Test performed in open system: no
- Details of trap for CO2 and volatile organics if used: Soda lime No. 1 was used for absorption of CO2
- Other:
SAMPLING
- Sampling frequency: Sampling was done continuously by an automatic measuring system (BOD measurement). The GC analysis was done at the end of the study.
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, one bottle
- Abiotic sterile control: no
- Toxicity control: no
- Other: reference substance: yes, one bottle; test substance + water: yes, one bottle - Reference substance:
- aniline
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 0
- Sampling time:
- 28 d
- Results with reference substance:
- 68% degradation after 14 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
Reference
Table 1: BOD measurements and % degradation during the study period
|
BOD [mg] and percent degradation |
|||||||
Test vessel |
7th day |
% |
14th day |
% |
21st day |
% |
28th day |
% |
Water + test item |
0.9 |
- |
3.1 |
- |
4.7 |
- |
6.1 |
- |
Sludge + test item |
0.9 |
-1 |
4.3 |
-3 |
6.4 |
-4 |
9.3 |
-4 |
Sludge + test item |
0.8 |
-1 |
4.9 |
0 |
7.4 |
0 |
9.9 |
-1 |
Sludge + test item |
0.7 |
-2 |
4.5 |
-2 |
6.9 |
-2 |
10.3 |
0 |
Control blank |
1.1 |
- |
5.0 |
- |
7.3 |
- |
10.2 |
- |
Sludge + aniline |
63.3 |
69 |
66.5 |
68 |
68.3 |
68 |
70.6 |
67 |
The test substance could not be measured by GC analysis at the end of the study. Therefore, it was considered that the substance may have been degraded to CO2 and absorbed by soda lime. After analysis the substance could not be measured in the absorber and only 1% of the substance was measured in test solution containing only test material and water. The reason of the low recovery in the test could not be revealed finally. One reason could be a loss of the substance by evaporation.
Description of key information
Not readily biodegradable: 0% (O2 consumption) after 28 d (OECD 301C)
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
One experimental study is available investigating the biodegradation of 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene (CAS 25291-17-2; Daikin Industries, 2007). The study was performed according to OECD 301C (GLP) using sewage sludge, surface water and surface soil which was in contact with the atmosphere from different locations as inoculum. An initial concentration of 100 mg/L was added to the test system and the biodegradation was measured by O2 consumption and by analytical determination via GC-analysis within a timeframe of 28 d. No biodegradation was recorded after 28 d and the substance is not considered to be readily biodegradable according to the OECD criteria (0% based on O2 consumption and test material analysis). Even though the substance has a high vapour pressure no decline of the initial test item concentration was measured at the end of the study period. The reference substance was degraded to 68% after 14 d confirming the suitability of the inoculum and the test system.
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