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EC number: 823-780-1 | CAS number: 1034820-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Justification of Read Across is given in Section 13 of IUCLID.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was tested for toxic and teratogenic effects to the developing chicken embryo.
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Dilauryl Thiodipropionate
- IUPAC Name:
- Dilauryl Thiodipropionate
Constituent 1
Test animals
- Species:
- other: chicken egg
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Route of administration:
- other: via air cell or via the yolk
- Vehicle:
- other: sesame oil
- Details on exposure:
- The test substance was administered in sesame oil by the two routes at two stages of embryonic development: via the air cell at pre-incubation (0 hours) and at 96 hours of incubation, and via the yolk at 0 hours and at 96 hours.
- Duration of treatment / exposure:
- 0 or 96 hours
- Frequency of treatment:
- single treatment
- Duration of test:
- until the chicks hatched
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.25 other: mg/egg (nominal)
- Remarks:
- corresponding to 5 mg/kg
- Dose / conc.:
- 0.5 other: mg/egg (nominal)
- Remarks:
- corresponding to 10 mg/kg
- Dose / conc.:
- 2.5 other: mg/egg (nominal)
- Remarks:
- corresponding to 50 mg/kg
- Dose / conc.:
- 5 other: mg/egg (nominal)
- Remarks:
- corresponding to100 mg/kg
- Dose / conc.:
- 10 other: mg/egg (nominal)
- Remarks:
- corresponding to 200 mg/kg
- No. of animals per sex per dose:
- 10 or more (not further specified)
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- The test substance was tested for toxic and teratogenic effects to the developing chicken embryo under four sets of conditions. It was administered in sesame oil as the solvent by the two routes at two stages of embryonic development: via the air cell at pre-incubation (0 hours) and at 96 hours of incubation, and via the yolk at 0 hours and at 96 hours using techniques that have been described previously*.
Groups of 10 or more eggs were treated under these four conditions at several dose levels until a total of ninety to one hundred eggs per level was reached for all levels allowing some to hatch. Groups of comparable size were treated with the solvent at corresponding volumes and untreated controls were also included in each experiment.
After treatment, all eggs were candled daily and non-viable embryos removed. Surviving embryos were allowed to hatch. All hatched chicks and non-viable embryos were examined carefully for abnormalities (internally and externally) as well as for toxic responses (such as oedema, haemorrhage, hypopigmentation of the down and other disorders such as feather abnormalities, significant groivth retardation, cachexia, ataxia or other nerve disorder; structural abnormality of the head, viscera, limbs, or body skeleton) and accidental deaths.
At hatchings, 3 chicks were removed at random from each level including control for skeletal clearing, weighing and fixing of bursa, spleen, liver and kidney. Tissues were processed, blocked in paraffin, sectioned, affixed to slides, and stained. Later these sections were examined for internal damage to the tissues.
* McLaughlin, J., Jr., Marliac, J.-P., Verrett, M. Jacqueline, Mutchler, Mary K., and Fitzhugh, O. G., (1963) Toxicol. Appl. Pharmacol. 5, 760-770; Verrett, M. J., Marliac, J.-P., and McLaughlin, J., Jr., (1964) JADAC 47, 1003-1006. - Statistics:
- Chi Square Test.
Results and discussion
Effect levels
- Remarks on result:
- not determinable
Observed effects
Applicant's summary and conclusion
- Conclusions:
- No teratogenic effects on the developing chicken embryo were observed in all the four test conditions.
- Executive summary:
The test substance was evaluated for its toxic and teratogenic potential to the developing chicken embryo under four sets of conditions. It was administered in sesame oil as the solvent by the two routes at two stages of embryonic development: via the air cell at pre-incubation (0 hours) and at 96 hours of incubation, and via the yolk at 0 hours and at 96 hours. Groups of 10 or more eggs were treated under these 4 conditions at several dose levels until a total of 90 -100 eggs/level was reached for all levels allowing some to hatch. Groups of comparable size were treated with the solvent at corresponding volumes and untreated controls were also included in each experiment. After treatment, all eggs were candled daily and non-viable embryos were removed. Surviving embryos were allowed to hatch. All hatched chicks and non-viable embryos were examined carefully for abnormalities (internally and externally) as well as for toxic responses (such as oedema, haemorrhage, hypopigmentation of the down and other disorders such as feather abnormalities, significant groivth retardation, cachexia, ataxia or other nerve disorder; structural abnormality of the head, viscera, limbs, or body skeleton) and accidental deaths. At hatchings, 3 chicks were removed at random from each level including control for skeletal clearing, weighing and fixing of bursa, spleen, liver and kidney. Tissues were processed, blocked in paraffin, sectioned, affixed to slides, and stained. These sections were examined for internal damage to the tissues.
There were no teratogenic effects observed in all the four test conditions employed.
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