Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to utilise EC 202-429-0 as a read-across source. See attached document for full justification.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Dutch Standardization Organization Method NEN 6501.
GLP compliance:
not specified
Remarks:
Study conducted in 1986. Endpoint from collected of data and compliance details are not available.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
not specified
Total exposure duration:
48 h

Test conditions

Hardness:
Not Specified
Test temperature:
Not Specified
pH:
Not Specified
Dissolved oxygen:
Not Specified
Salinity:
Not Specified
Conductivity:
Not Specified
Nominal and measured concentrations:
Not Specified
Details on test conditions:
Not Specified
Reference substance (positive control):
not specified

Results and discussion

Effect concentrations
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
0.52 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
not specified
Details on results:
A test on the acute toxicity of o-toluidine to the invertebrate Daphnia magna was performed
according to the Dutch Standardization Organization Method NEN 6501. For a test period of
48 hours an EC50 value of 0.52 mg/l was reported (Maas-Diepeveen and van Leeuwen, 1986).

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
A test on the acute toxicity of o-toluidine to the invertebrate Daphnia magna was performed according to the Dutch Standardization Organization Method NEN 6501. For a test period of 48 hours an EC50 value of 0.52 mg/l was reported (Maas-Diepeveen and van Leeuwen, 1986).

Classified as H410 Aquatic Chronic 1 and H400 Aquatic Acute 1.
Executive summary:

A test on the acute toxicity of o-toluidine to the invertebrate Daphnia magna was performed according to the Dutch Standardization Organization Method NEN 6501. For a test period of 48 hours an EC50 value of 0.52 mg/l was reported (Maas-Diepeveen and van Leeuwen, 1986).

Data from OECD SIDS assessed and used as basis for read across report.

Classified as H410 Aquatic Chronic 1 and H400 Aquatic Acute 1.