Registration Dossier
Registration Dossier
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EC number: 812-526-5 | CAS number: 53831-80-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Considering the structural similarities of both molecules and the probability to act via a common mode of action, it is acceptable to utilise EC 202-429-0 as a read-across source. See attached document for full justification.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Study conducted in 1979 no guideline available.
- GLP compliance:
- not specified
- Remarks:
- Study conducted in 1979.
- Test type:
- other: Oral administration of 50 mg/kg bw o-toluidine to 2 cats per sex
Test material
- Reference substance name:
- o-toluidine
- EC Number:
- 202-429-0
- EC Name:
- o-toluidine
- Cas Number:
- 95-53-4
- Molecular formula:
- C7H9N
- IUPAC Name:
- o-toluidine
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- cat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 1
- No. of animals per sex per dose:
- 2 animals per sex per dose (50 mg/kg only)
- Control animals:
- not specified
- Details on study design:
- Oral administration of 50 mg/kg bw o-toluidine to 2 cats per sex, observation over 14 day period.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 of 4 cats died during 14 day observation period.
- Clinical signs:
- ateral position, tachypnea, cyanosis mydriasis, apathy, salivation
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- Oral administration of 50 mg/kg bw o-toluidine to 2 cats per sex resulted in 59.6 to 71.7 % methemoglobin within 4 hours after administration.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- Oral administration of 50 mg/kg bw o-toluidine to 2 cats per sex resulted in 59.6 to 71.7 % methemoglobin
within 4 hours after administration, lateral position, tachypnea, cyanosis mydriasis,
apathy, salivation and the death of one cat. During the 14 day-observation period, one cat was in
poor condition and 2 cats recovered (BASF AG, 1979).
Classified as Category 2 for acute oral toxicity - Executive summary:
Oral administration of 50 mg/kg bw o-toluidine to 2 cats per sex resulted in 59.6 to 71.7 % methemoglobin
within 4 hours after administration, lateral position, tachypnea, cyanosis mydriasis,
apathy, salivation and the death of one cat. During the 14 day-observation period, one cat was in
poor condition and 2 cats recovered (BASF AG, 1979).
Classified as Category 2 for acute oral toxicity
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