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Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
(Q)SAR analysis, no study period available
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
See attached document for justification of the use of (Q)SAR calculation.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
(Q)SAR analysis - guideline not applicable
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
In Silico Study

Study design

Oxygen conditions:
not specified
Remarks:
(Q)SAR
Inoculum or test system:
not specified
Remarks:
(Q)SAR

Results and discussion

% Degradation
Key result
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Value:
0.091
St. dev.:
0
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction
Details on results:
Calculation using BIOWIN V4.10 gives MITI probability of biodegradation 0.0910, predicted not to be readily biodegradable.
Totxtree (decision treeapproach) gave the result of Class 2 persistent chemical.

The results are in alignment and therefore the conclusion is drawn that the substance will not be readily biodegradable.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Interpretation of results:
not readily biodegradable
Conclusions:
Calculation using BIOWIN V4.10 gives MITI probability of biodegradation 0.0910, predicted not to be readily biodegradable.
Totxtree (decision treeapproach) gave the result of Class 2 persistent chemical.

The results are in alignment and therefore the conclusion is drawn that the substance will not be readily biodegradable.
Executive summary:

Calculation using BIOWIN V4.10 gives MITI probability of biodegradation 0.0910, predicted not to be readily biodegradable.

Totxtree (decision treeapproach) gave the result of Class 2 persistent chemical.

The results are in alignment and therefore the conclusion is drawn that the substance will not be readily biodegradable.