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EC number: 293-106-3
CAS number: 91051-53-5
The biological results are expressed on the basis of loading rates,
since the test item is characterised as an UVCB, and, also on measured
time-weighted average concentrations.
Based on Loading Rates :
Growth Rate -
ErL50 (72 hour) > 100 mg/L
NOErL (72 hour) = 32 mg/L
Based on Yield -
EyL50 (72 hour) > 100 mg/L
NOEyL (72 hour) = 32 mg/L
Based on measured Time-Weighted Average Concentrations :
ErC50 (72 hour) > 0.38 mg/L (> saturation concentration)
NOErC (72 hour) = 0.32 mg/L
EyC50 (72 hour) > 0.38 mg/L (> saturation concentration)
NOEyC (72 hour) = 0.32 mg/L
One study investigating the short-term toxicity of the test
substance to freshwater algae is available. The test was performed
according to GLP and OECD guideline 201 using Pseudokirchneriella
subcapitata as test organism. An EC50 test was performed based on
the results of two preceding tests, i.e. a combined limit/range-finder
and an EC50 test with a narrower range of concentrations. Exponentially
growing algal cultures were exposed to a control and WAFs prepared at
loading rates of 1.0, 3.2, 10, 32 and 100 mg/L. Samples for analytical
confirmation of actual exposure concentrations were taken at the start
and after 24 and 72 hours of exposure.
Samples taken from the 32 and 100 mg/L loading rates were analyzed
and showed initial concentrations of 9.3 and 14 mg/L, respectively.
These concentrations decreased below the area of the lowest calibration
solution, i.e. below 0.14 mg/L within 24 hours of exposure. Note that
some undissolved test substance particles were observed at the loading
rates of 32 and 100 mg/L from 24 hours of exposure onwards indicating
that it was likely that the start concentrations exceeded the actual
solubility limit. The Time Weight Average (TWA) exposure concentrations
at the 32 and 100 mg/L loading rates were calculated to be 0.32 and 0.38
Both the EC50 for growth rate reduction and yield inhibition
exceeded a glass-wool filtered WAF that was obtained from a loading rate
of 100 mg/L, i.e. exceeded a TWA concentration of 0.38 mg/L. The NOEC
for both growth rate reduction and yield Inhibition equaled the
concentration present in a glass-wool filtered WAF prepared at a loading
rate of 32 mg/L. The corresponding TWA concentration is 0.32 mg/L. Based
on this result, the substance is not considered to be acutely harmful to
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