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Hydrolysis

HYDROWIN v2.00 program of Estimation Programs Interface prediction model (2018) was used to predict the hydrolysis half-life of test compound Castor oil, sulfated (CAS No. 8002 -33 -3). The estimated half-life of Castor oil, sulfated was determined to be 1.510 years at pH 7.0 and 55.135 days at pH 8.0 (at 25ᵒC) respectively, indicating that it is not hydrolysable.

Additional information

Hydrolysis

Predicted data for the target chemical Castor oil, sulfated (CAS No. 8002-33-3) and various supporting weight of evidence studies for its structurally and functionally similar read across substance were reviewed for the hydrolysis end point which are summarized as below:

 

For target chemicalCastor oil, sulfated(CAS No. 8002-33-3), HYDROWIN v2.00 program of Estimation Programs Interface (modelling database, 2018) prediction model was used to predict the hydrolysis half-life of test compoundCastor oil, sulfated. The estimated half-life of Castor oil, sulfated was determined to be 1.510 years at pH 7.0 and 55.135 days at pH 8.0 (at 25ᵒC) respectively, indicating that it is not hydrolysable.

 

In a supporting weight of evidence study from authoritative database (2017), the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant was determined to be 0.15L/mol-sec with a corresponding half-lives of 1.5 yrs and 55 days at pH 7 and 8, respectively.

 

For the test chemical, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method (authoritative database, 2016). The second order hydrolysis rate constant of test chemical was determined to be 0.077 L/mol-sec with a corresponding half-lives of 2.8 yrs and 104 days at pH 7 and 8, respectively.

 

In an another supporting weight of evidence study from authoritative database (2016),the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.15L/mol-sec with a corresponding half-lives of 1.5 yrs and 55 days at pH 7 and 8, respectively.

 

On the basis of the above results for target chemical Castor oil, sulfated (from modelling database, 2018), it can be concluded that the test chemical Castor oil, sulfated is not hydrolysable.