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Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance raw materials monographs :p-METHOXYPHENYLACETONE
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology,Volume 17, Supplement, Pages 695-923 (December 1979)
Reference Type:
other: Authoritative database
Title:
Acute oral toxicity study of 4-Methoxyphenylacetone (122-84-9) in rats
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
secondary source
Title:
The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients
Author:
T.B. Adams ,M.M. McGowen , M.C. Williams , S.M. Cohen , V.J. Feron ,J.I. Goodman , L.J. Marnett , I.C. Munro, P.S. Portoghese,R.L. Smith , W.J. Waddell
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45 (2007) 171–201
Reference Type:
review article or handbook
Title:
Acute oral toxicity study of 2-Propanone, 1-(4-methoxyphenyl)- (122-84-9) in rat
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
Reference Type:
secondary source
Title:
Acute oral toxicity - rabbit
Author:
RTECS
Year:
1997
Bibliographic source:
RTECS
Reference Type:
secondary source
Title:
SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANT S AROMATIC SUBSTITUTED SECONDARY ALCOHOLS, KETONES, AND RELATED ESTERS
Author:
World Health Organization
Year:
1978
Bibliographic source:
SAFETY EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANT S AROMATIC SUBSTITUTED SECONDARY ALCOHOLS, KETONES, AND RELATED ESTERS, World Health Organization ,WHO FOOD ADDITIVES SERIES: 48,1978
Reference Type:
secondary source
Title:
Acute oral toxicity study of 2-Propanone, 1-(4-methoxyphenyl)- (122-84-9) in Rat
Author:
U.S. Environmental Protection Agency. Chemistry Dashboard
Year:
2018
Bibliographic source:
Chemistry Dashboard, U.S. Environmental Protection Agency,2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of 4-Methoxyphenylacetone (122-84-9) on rats.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methoxyphenylacetone
EC Number:
204-578-7
EC Name:
4-methoxyphenylacetone
Cas Number:
122-84-9
Molecular formula:
C10H12O2
IUPAC Name:
1-(4-methoxyphenyl)acetone
Details on test material:
- Name of test material (IUPAC name): 1-(4-methoxyphenyl)propan-2-one
- Common name: 4-Methoxyphenylacetone
- Molecular formula: C10H12O2
- Molecular weight: 164.203 g/mol
- Smiles notation: c1(ccc(OC)cc1)CC(C)=O
- InChl: 1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):p-Methoxyphenylacetone
- Molecular formula :C10H12O2
- Molecular weight :164.203 g/mol
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
3330 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
Details on study design:
- Duration of observation period following administration: No data available
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: Clinical signs
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 330 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% Mortality was observed in treated rats at 3330 mg/kg bw
Mortality:
50% Mortality was observed in treated rats at 3330 mg/kg bw
Clinical signs:
Clinical signs like tremor,changes in motor activity (Specific assay) and altered sleep time (including change in righting reflex) were observed.
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 3330 mg/kg bw,when rats were treated with 4-Methoxyphenylacetone (122-84-9) orally.
Executive summary:

Acute oral toxicity study was done in rats using test material 4-Methoxyphenylacetone (122-84-9).50% Mortality was observed at dose 3330 mg/kg bw.Clinical signs like tremor, changes in motor activity(Specific assay) and altered sleep time (including change in righting reflex) were observed.Hence,LD50 value was considered to be 3330 mg/kg bw,when rats were treated with 4-Methoxyphenylacetone (122-84-9) orally.