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Hydrolysis:

The half life of hydrolysis of test chemical 1-(4-methoxyphenyl)acetone (CAS no.122 -84 -9) was estimated by using OECD QSAR tool box v3.3 by considering seven closest read across chemicals with log KOw as primary descriptor. The half life of hydrolysis of test chemical 1-(4-methoxyphenyl)acetone (CAS no. 122-84-9) was estimated to be 59.94 days. On the basis of this half life value it can be concluded that test chmeical 1-(4-methoxyphenyl)acetone is not hydrolysable.

Additional information

Hydrolysis:

Predicted data study for target chemical 1-(4-methoxyphenyl)acetone (CAS no.122 -84 -9) and experimental study for its structurally similar read across chemical have been studied and their results are summarized below for hydrolysis in water endpoint.

In a predicted data study the half life of hydrolysis of test chemical 1-(4-methoxyphenyl)acetone (CAS no.122 -84 -9) was estimated by using OECD QSAR tool box v3.3 by considering seven closest read across chemicals with log KOw as primary descriptor. The half life of hydrolysis of test chemical 1-(4-methoxyphenyl)acetone (CAS no. 122-84-9) was estimated to be 59.94 days. On the basis of this half life value it can be concluded that test chemical 1-(4-methoxyphenyl)acetone is not hydrolysable.

Next study was experimental study done from authoritative database (HSDB, 2017) in this study the half life of hydrolysis of read across chemical 2-(4-chlorophenoxy)acetic acid (CAS no. 122-88-3) was determined to be > 30 days at pH 5, 7 and 9. On the basis of this half life value it is concluded that read across chemical is not hydrolysable i.e., stable to hydrolysis in water.

On the basis of both the studies mentioned above it can be concluded that test chemical1-(4-methoxyphenyl)acetone is not hydrolysable i.e., it is stable to hydrolysis.

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