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EC number: 204-578-7 | CAS number: 122-84-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Gene mutation in vitro:
Ames assay:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, gene mutation was predicted for 1-(4-methoxyphenyl)acetone. The study assumed the use of Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and TA 102 with S9 metabolic activation system. 1-(4-methoxyphenyl)acetone was predicted to not induce gene mutation in Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and TA 102 in the presence of S9 metabolic activation system and hence, according to the prediction made, it is not likely to classify as a gene mutant in vitro.
Based on the predicted result it can be concluded that the substance is considered to not toxic as per the criteria mentioned in CLP regulation.
Chromosomal aberration assay:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, chromosomal aberration was predicted for 1-(4-methoxyphenyl)acetone. The study assumed the use of Chinese hamster ovary (CHO) cell line with and without S9 metabolic activation system. 1-(4-methoxyphenyl)acetone was predicted to not induce chromosomal aberrations in Chinese hamster ovary (CHO) cell line in the presence and absence of S9 metabolic activation system and hence, according to the prediction made, it is not likely to classify as a gene mutant in vitro.
Based on the predicted result it can be concluded that the substance is considered to not toxic as per the criteria mentioned in CLP regulation.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Gene mutation in vitro:.
Prediction model based estimation for the target chemical and data from target and read across chemicals have been reviewed to determine the mutagenic nature of 1-(4-methoxyphenyl)acetone. The studies are as mentioned below:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, gene mutation was predicted for 1-(4-methoxyphenyl)acetone. The study assumed the use of Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and TA 102 with S9 metabolic activation system. 1-(4-methoxyphenyl)acetone was predicted to not induce gene mutation in Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and TA 102 in the presence of S9 metabolic activation system and hence, according to the prediction made, it is not likely to classify as a gene mutant in vitro.
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, chromosomal aberration was predicted for 1-(4-methoxyphenyl)acetone. The study assumed the use of Chinese hamster ovary (CHO) cell line with and without S9 metabolic activation system. 1-(4-methoxyphenyl)acetone was predicted to not induce chromosomal aberrations in Chinese hamster ovary (CHO) cell line in the presence and absence of S9 metabolic activation system and hence, according to the prediction made, it is not likely to classify as a gene mutant in vitro.
Gene mutation toxicity was predicted for 1-(4-methoxyphenyl)acetone using the battery approach from Danish QSAR database (2018). The study assumed the use of Salmonella typhimurium bacteria in the Ames test. The end point for gene mutation has been modeled in the Danish QSAR using the three software systems Leadscope, CASE Ultra and SciQSAR. Based on predictions from these three systems, a fourth and overall battery prediction is made. The battery prediction is made using the so called Battery algorithm. With the battery approach it is in many cases possible to reduce “noise” from the individual model estimates and thereby improve accuracy and/or broaden the applicability domain. Gene mutation toxicity study as predicted by Danish QSAR for 1-(4-methoxyphenyl)acetone is negative and hence the chemical is predicted to not classify as a gene mutant in vitro.
The ability of 1-(4-methoxyphenyl)acetone to induce chromosomal aberration was predicted using Chinese hamster lung cells (CHL) using Danish QSAR database (2018). The end point for chromosome aberrations has been modeled in the Danish QSAR using the three software systems Leadscope, CASE Ultra and SciQSAR. Based on predictions from these three systems, a fourth and overall battery prediction is made. The battery prediction is made using the so called Battery algorithm. With the battery approach it is in many cases possible to reduce “noise” from the individual model estimates and thereby improve accuracy and/or broaden the applicability domain. 1-(4-methoxyphenyl)acetone does not induce chromosome aberrations in Chinese hamster lung cells (CHL) and hence is predicted to not classify as a gene mutant in vitro.
The predicted data is further supported by the data from target chemical and its read across chemicals as mentioned below:
Gene mutation toxicity study was performed by Wild et al (Food and chemical toxicology, 1983) to determine the mutagenic nature of 80 -90% sttructurally and functionally similar read across chemical 4-(4-Methoxyphenyl)butan-2-one (RA CAS no: 104 -20 -1; IUPAC name: Anisyl acetone). The study was perfomed as per the standard plate procesdure using Salmonella typhimurium strains TA1535, TA100, TA1537, TA1538, TA98 in the presence and absence of S9 metabolic activation system. The test chemical was dissolved in DMSO and used upto doses of 3.6 mg/plate. The plates were incubated for 48 hrs. 4-(4-Methoxyphenyl)butan-2-one (Anisyl acetone) did not induce gene mutation in Salmonella typhimurium strains TA1535, TA100, TA1537, TA1538, TA98, test substance in the presence and absence of S9 metabolic activation system and hence it is not likely to classify as a gene mutant.
In a study by Rapson et al (Bulletin of Environmental Contamination and Toxicology, ) Gene mutation toxicity study was performed to determine the mutagenic nature of the 70 -80% structurally and functionally similar read across chemical p-methoxyacetophenone (RA CAS no 100 -06 -1) at dose levels of 0.1, 1, 10, 100 or 1000 µg/plate. The study was performed as part of mutagenicity produced by aqueous chlorination of organic compounds. p-methoxy acetophenone is not mutagenic in the bacterium Salmonella typhimurium TA 100 and hence is not likely to classify as gene mutant in vitro.
Gene mutation toxicity study was performed by Florin et al (Toxicology, 1980) to determine the mutagenic nature of the 50 -60% strycturally and functionally simlar read across chemical Anisole (RA CAS no 100 -66 -3) using Salmonella typhimurium LT-2 strains TA 98, TA 100, TA 1535, and TA 1537. The material was dissolved in ethanol and applied at a concentration of 3 µmole/plate in the spot test performed. Anisole is not mutagenic in the bacterium Salmonella typhimurium LT-2 strains TA 98, TA 100, TA 1535, and TA 1537 with and without S9 metabolic activation system and hence is not likely to classify as gene mutant in vitro.
Based on the data available for the target chemical and its read across, 1-(4-methoxyphenyl)acetone does not exhibit gene mutation in vitro. Hence the test chemical is not likely to classify as a gene mutant as per the criteria mentioned in CLP regulation.
Justification for classification or non-classification
Based on the data available for the target chemical and its read across, 1-(4-methoxyphenyl)acetone (CAS no 122 -84 -9) does not exhibit gene mutation in vitro. Hence the test chemical is not likely to classify as a gene mutant as per the criteria mentioned in CLP regulation.
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