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EC number: 214-011-5 | CAS number: 1072-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral LD50 = 1400 mg/kg bw, mortality was observed (BASF, 1967)
Dermal LD50 > 200 mg/kg bw, no mortality observed (BASF, 1980)
Inhalation LC50 > 0.015 mg/L air (BASF, 1967), LC50 >0.03 mg/L air (BASF, 1980)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967-07-04 to 1967-07-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP but equivalent to guideline study.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: "US" rats
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2, 8, 10 and 16% (w/v) - Doses:
- 200, 800, 1250 and 1600 mg/kg
- No. of animals per sex per dose:
- 10 per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 and 800 mg/kg: no deaths; 1250 mg/kg: 3/10 after 7 days; 1600 mg/kg: 8/10 after 7 days
- Clinical signs:
- Dyspnea, apathy, abdominal and lateral position
- Gross pathology:
- Animals that died: all animals with bloody-serous snouts and blurred anus; 1 x diarrhea, 1 x severe distended ectatic stomach, 1 x suspicion of necrosis and hemorrhages of the liver (with putrescence)
Sacrificed animals: nothing abnormal detected - Interpretation of results:
- Category 4 based on GHS criteria
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 400 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: orientating information about the inhalation hazard
- Principles of method if other than guideline:
- according to H.F. Smyth et al.: Am. Ind. Hyg. Ass. J. 23, 95-107 (1962)
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga, Sulzfeld, Germany
- Diet: ad libitum, Herilan MRH, Eggersmann KG, Rinteln, Germany
- Water: ad libitum - Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The findings of the test depend on the toxicity and volatility of the product.
The product was filled to a height of 5 cm in a fritted glass flask, which had been placed in a water bath maintained at 20°C. A flow of air of 200 liter/hour was conducted through the product. The atmosphere enriched with the possibly volatile components of the test substance in this way was passed through a glass distributor to glass inhalation chambers (tubes) in which one rat had been placed in each case. The exposure periods were 3, 10 and 30 minutes and 1, 3 and 7 hours. The time of exposure was determined at which all animals survived. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 7 h
- Concentrations:
- mean concentration: 0.03 mg/L
- No. of animals per sex per dose:
- 12
- Control animals:
- no
- Details on study design:
- The post-exposure observation period was 14 days.
The signs of toxicity and mortality of the test animals were recorded. The animals that died or those sacrificed with carbon dioxide at the end of the post-exposure observation period were subjected to a gross-pathological examination. - Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.03 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- Sacrificed animals: organs: nothing abnormal detected
- Interpretation of results:
- other: The inhalation of a saturated vapor-air-mixture represents an unlikely acute hazard.
Reference
Endpoint conclusion
- Quality of whole database:
- No guideline study, only orientating information about the inhalation hazard is given.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report. Basic information is given. Only tested up to 200 mg/kg
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal standard and DOT guidelines
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Mean weight for male animals 2.9 kg, female animals: 2.9 kg
The animals received Ssniff K standard diet for rabbits and guinea pigs supplied by INTERMAST GMBH, Soest, FRG, and water ad libitum.
TEST ANIMALS
- Source: Breeding facility M. Gaukler, 6050 Offenbach, Germany
- Weight at study initiation: mean weight 2.9 kg for males and females
- Diet: ad libitum (Ssniff K, standard diet, INTERMAST GMBH, Soest, Germany)
- Water: ad libitum - Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flank
- coverage: 50 cm2
- Type of wrap if used: inert foil fixed with an adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water or a mixture of water and lutrol
- Time after start of exposure: 24 hours
TEST MATERIAL
- Concentration: 50 % aqueous solution
- For solids, paste formed: no - Duration of exposure:
- 24 hours
- Doses:
- 200 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations and weighing: after 1, 24, 48 h and on Day 8
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- Signs of systemic toxicity: none
Signs of local irritation: initial slight reddening, reversible within 8 days - Body weight:
- Not observed
- Gross pathology:
- No substance-related organ findings
- Conclusions:
- The acute dermal toxicity of the test substance in Vienna white rabbits was determined. The product was applied as a 50% aqueous test substance preparation by single dose of 200 mg/kg for 24 hours on clipped areas (about 50 cm2) of the back and flanks. The determination of the LD50 was based on the DOT guidelines, but no exact LD50 was established.
Reference
Additional information
Acute oral toxicity:
In an acute oral toxicity study, a single oral dose of the test
substance at dose levels of 200, 800, 1250 and 1600 mg/kg bw (BASF,
1967) was administered to "US" rat (5/sex/group).
Animals were then observed for 7 days. No
mortality was observed up to a dose of 800 mg/kg bw. After 7 days three
out of ten animals died at 1250 mg/kg bw and eight out of ten died at
the highest tested dose. Animals showed dyspnea, apathy and abdominal
and lateral position. All deceased animals showed a bloody-serous snout
and blurred anus. Diarrhea, severe distended ectatic stomach and
suspicion of necrosis and hemorrhages of the liver were observed each in
one animal. The sacrificed animals did not show any gross internal
lesions.
An approximate LD50 of 1400 mg/kg bw was reported.
Acute inhalation toxicity:
In an acute inhalation toxicity study according to H.F. Smyth et
al.: Am Ind. Hyg. Ass. J. 23, 95 -107 (1962), groups of Spargue-Dawley
rats (12/sex) were tested at the technical maximal attainable
concentration. The mean concentration was 0.03 mg/L air. The exposure
periods were 3, 10 and 30 minutes and 1, 3 and 7 hours. The time of
exposure was determined at which all animals survived: After 7 hours of
exposure tno animals died. Animals then were observed for 14 days (BASF
AG, 1980).
In an acute inhalation toxicity study according to BASF-internal
standard (BASF, 1967), groups of 12 rats per sex were exposed to an at
20 °C with dust enriched atmosphere of the test substance
(concentration: 0.015 mg/L air) for 8 hours. After the exposure time no
animals have died and no abnormalities was observed. One animal showed a
chronic bronchitis.
Both acute inhalation toxicity studies were not performed according to
an OECD Guideline. Conclusions on the acute inhalation toxicity are not
possible because the data provided do not allow the calculation of an
LC50. But based on the study results it can be concluded that the LC50
of the test substance is > 0.03 mg/L air and the inhalation of a saturated
vapor-air mixture represents an unlikely acute hazard..
Acute dermal toxicity:
In an acute dermal toxicity study, groups of Vienna White rabbits
(5/sex) were dermally exposed to the test substance as a 50% aqueous
test substance preparation by single dose of 200 mg/kg for 24 hours on
clipped areas (about 500 cm²) of the back and flanks. Animals then were
observed for 8 days. No mortality occurred within 8 days and a LD50
greater than 200 mg/kg was determined.
Justification for classification or non-classification
Classification, Labelling, and Packaging
Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for
classification purposes under Regulation 1272/2008 (CLP). As a result
the substance is considered to be classified for acute oral toxicity
under Regulation (EC) No 1272/2008, as amended for the sixth time in
Regulation (EC) No 605/2014 as follows: acute toxicity: cat. 4, H302,
harmful if swallowed.
Dangerous Substance Directive
(67/548/EEC)
The available studies are considered reliable and suitable for
classification purposes under 67/548/EEC. As a result the substance is
considered to be classified for acute oral toxicity under Directive
67/548/EEC, as amended for the 31st time in Directive 2009/2/EG as
follows: R22, harmful if swallowed.
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