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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: orientating information about the inhalation hazard

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report Date:
1980

Materials and methods

Principles of method if other than guideline:
according to H.F. Smyth et al.: Am. Ind. Hyg. Ass. J. 23, 95-107 (1962)
GLP compliance:
no
Test type:
other: inhalation hazard test

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Wiga, Sulzfeld, Germany
- Diet: ad libitum, Herilan MRH, Eggersmann KG, Rinteln, Germany
- Water: ad libitum

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
The findings of the test depend on the toxicity and volatility of the product.
The product was filled to a height of 5 cm in a fritted glass flask, which had been placed in a water bath maintained at 20°C. A flow of air of 200 liter/hour was conducted through the product. The atmosphere enriched with the possibly volatile components of the test substance in this way was passed through a glass distributor to glass inhalation chambers (tubes) in which one rat had been placed in each case. The exposure periods were 3, 10 and 30 minutes and 1, 3 and 7 hours. The time of exposure was determined at which all animals survived.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
7 h
Concentrations:
mean concentration: 0.03 mg/L
No. of animals per sex per dose:
12
Control animals:
no
Details on study design:
The post-exposure observation period was 14 days.
The signs of toxicity and mortality of the test animals were recorded. The animals that died or those sacrificed with carbon dioxide at the end of the post-exposure observation period were subjected to a gross-pathological examination.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
0.03 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
7 h
Mortality:
None
Clinical signs:
other: None
Gross pathology:
Sacrificed animals: organs: nothing abnormal detected

Applicant's summary and conclusion

Interpretation of results:
other: The inhalation of a saturated vapor-air-mixture represents an unlikely acute hazard.