2-ethylimidazole

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: orientating information about the inhalation hazard

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Principles of method if other than guideline:

according to H.F. Smyth et al.: Am. Ind. Hyg. Ass. J. 23, 95-107 (1962)

GLP compliance:

no

Test type:

other: inhalation hazard test

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylimidazole

EC Number:

214-011-5

EC Name:

2-ethylimidazole

Cas Number:

1072-62-4

Molecular formula:

C5H8N2

IUPAC Name:

2-ethylimidazole

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Wiga, Sulzfeld, Germany
- Diet: ad libitum, Herilan MRH, Eggersmann KG, Rinteln, Germany
- Water: ad libitum

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

The findings of the test depend on the toxicity and volatility of the product.
The product was filled to a height of 5 cm in a fritted glass flask, which had been placed in a water bath maintained at 20°C. A flow of air of 200 liter/hour was conducted through the product. The atmosphere enriched with the possibly volatile components of the test substance in this way was passed through a glass distributor to glass inhalation chambers (tubes) in which one rat had been placed in each case. The exposure periods were 3, 10 and 30 minutes and 1, 3 and 7 hours. The time of exposure was determined at which all animals survived.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

mean concentration: 0.03 mg/L

No. of animals per sex per dose:

12

Control animals:

no

Details on study design:

The post-exposure observation period was 14 days.
The signs of toxicity and mortality of the test animals were recorded. The animals that died or those sacrificed with carbon dioxide at the end of the post-exposure observation period were subjected to a gross-pathological examination.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

0.03 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

7 h

Mortality:

None

Clinical signs:

other: None

Gross pathology:

Sacrificed animals: organs: nothing abnormal detected

Applicant's summary and conclusion

Interpretation of results:

other: The inhalation of a saturated vapor-air-mixture represents an unlikely acute hazard.