Registration Dossier
Registration Dossier
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EC number: 214-011-5 | CAS number: 1072-62-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967-07-04 to 1967-07-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP but equivalent to guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylimidazole
- EC Number:
- 214-011-5
- EC Name:
- 2-ethylimidazole
- Cas Number:
- 1072-62-4
- Molecular formula:
- C5H8N2
- IUPAC Name:
- 2-ethylimidazole
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: "US" rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2, 8, 10 and 16% (w/v) - Doses:
- 200, 800, 1250 and 1600 mg/kg
- No. of animals per sex per dose:
- 10 per dose level
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 200 and 800 mg/kg: no deaths; 1250 mg/kg: 3/10 after 7 days; 1600 mg/kg: 8/10 after 7 days
- Clinical signs:
- Dyspnea, apathy, abdominal and lateral position
- Gross pathology:
- Animals that died: all animals with bloody-serous snouts and blurred anus; 1 x diarrhea, 1 x severe distended ectatic stomach, 1 x suspicion of necrosis and hemorrhages of the liver (with putrescence)
Sacrificed animals: nothing abnormal detected
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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