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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01. Sep - 02. Sep 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
GLP compliance:
no
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Specific details on test material used for the study:
Storage conditions: Ambient temperature (10 to 30 °C), protected from light
Key result
Temp.:
ca. 20 °C
Vapour pressure:
< 0 hPa
Key result
Temp.:
ca. 25 °C
Vapour pressure:
< 0 hPa
Key result
Temp.:
ca. 50 °C
Vapour pressure:
< 0 hPa

Results
Vapour pressure was measured in a range of 30 to 60 °C. Measurements at higher temperatures were not possible as in a preliminary DSC measurement an exothermal effect was seen starting at ca. 90 °C. Thus, it cannot be excluded that the higher measured points were already influenced by decomposition of the test item.

Table 1 – Measured vapour pressures and corresponding temperatures

Temperature [°C]

Vapour pressure [hPa]

30

1.2E-06

35

*

40

3.8E-07

45

8.8E-07

50

2.6E-06

55

4.4E-06

60

6.7E-06

*measurement not evaluable

The test did not yield vapour pressure sufficiently high to extrapolate to 20, 25 and 50 °C. Therefore, these were estimated using the Antoine equation (Eq. 1). A value of 273.15 was used for constant C, and a value of -5000 for constant B. The detection limit (1E-05 hPa) at the highest measurement point (60 °C) was used for the calculation, as all measured vapour pressure values were below the detection limit. Constant A was calculated to be equal to 10.01.

Table 2 – Calculated vapour pressures

T [°C]

p [hPa]

p [Pa]

20

< 9.0E-08

< 9.0E-06

25

< 1.7E-07

< 1.7E-05

50

< 3.4E-06

< 3.4E-04

Conclusions:
The vapour pressure of the test item was determined to be < 9E-6 Pa (20 °C), <1.7E-5 Pa (25 °C) and < 3.4E-4 Pa (50 °C).
Executive summary:

A study was performed according to OECD TG 104 and Commission Regulation (EC) No. 440/2008, method A.4 in order to determine the vapour pressure of the test item by using the effusion method. The vapour pressure was measured using the Knudsen cell at various temperatures between about 30 and 60 °C. The vapour pressures of the test item at 20, 25 and 50 °C were extrapolated by using the Antoine constants with following results: < 9E-6 Pa (20 °C), <1.7E-5 Pa (25 °C) and < 3.4E-4 Pa (50 °C).

Description of key information

A study was performed according to OECD TG 104 and Commission Regulation (EC) No. 440/2008, method A.4 in order to determine the vapour pressure of the test item by using the effusion method. The vapour pressure was measured using the Knudsen cell at various temperatures between about 30 and 60 °C. The vapour pressures of the test item at 20, 25 and 50 °C were extrapolated by using the Antoine constants with following results: < 9E-6 Pa (20 °C), < 1.7E-5 Pa (25 °C) and < 3.4E-4 Pa (50 °C).

Key value for chemical safety assessment

Additional information

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