Tungsten hexachloride

Endpoint summary

Description of key information

In accordance with REACH Regulation (EC) No 1907/2006, Annex VIII, column 2 of information requirement section 8.5, no acute toxicity testing need to be conducted since the test item is classified as corrosive to the skin (Cat. 1B/C).

Supporting information is available from a report of the Agency for Toxic Substances and Disease Registry (ATSDR 2005). In this report, a publication is cited applying a 5 % solution of Tungsten hexachloride to the rabbit skin. All animals died in the mid and high dose group (200 and 1000 mg/kg b.w.) and none in the low dose group (100 mg/kg b.w.).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as corrosive to the skin

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as corrosive to the skin

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Reference 1

Endpoint:

acute toxicity: dermal

Type of information:

other: Entry of the Agency for Toxic Substances and Disease Registry

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Species:

rabbit

Details on dermal exposure:

Single application of a 5 % Tungsten hexachloride solution

Doses:

100, 200 and 1000 mg/kg bw

No. of animals per sex per dose:

2 rabbits per dose group

Sex:

not specified

Dose descriptor:

other: LOAEL

Effect level:

200 mg/kg bw

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 100 - < 200 mg/kg bw

Mortality:

In the high and mid dose all animals died after dosing. No deaths in the low dose group.

No information was located regarding mechanisms involved in absorption of tungsten through the skin. However, a report of death in rabbits following a single dermal application of a 5% tungsten chloride solution (Dow Chemical Company 1982) is evidence of absorption and systemic distribution of dermally applied tungsten.

Relatively little information is available concerning adverse effects in animals following acute-duration dermal exposure to tungsten. Contact dermatitis was reported in rabbits following dermal application of a 5% tungsten chloride solution in single doses ≥100 mg/kg; doses ≥200 mg/kg also resulted in death (Dow Chemical Company 1982). Instillation of a 5% tungsten chloride solution into the rabbit eye resulted in initial ocular irritation that resolved within 14 days postinstillation (Dow Chemical Company 1982).

Interpretation of results:

study cannot be used for classification

Conclusions:

No LD50 value can be determined based on this publication.

Executive summary:

A publication of the Dow Chemical Company (1982) on the toxicological properties of Tungsten hexachloride was citied in the report of the Agency for Toxic Substances and Disease Registry (2005) on the “Toxicological profile for Tungsten”. In this study two rabbits per dose group were dermally exposed to a 5 % solution of Tungsten hexachloride in absolute doses of 100, 200 and 1000 mg/kg body weight. While all animals died in the high and mid dose groups, the animals of the low dose developed contact dermatitis. An LD50 value can not be calculated based on these data. When instilled to the eye the 5% solution of Tungsten hexachloride caused temporary ocular irritation.

Reference 2

Endpoint:

acute toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as corrosive to the skin

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Justification for classification or non-classification

In accordance with REACH Regulation (EC) No 1907/2006, Annex VIII, column 2 of information requirement section 8.5 no acute toxicity studies need to be conducted as the test item is classified as corrosive to the skin (Cat. 1B/C).