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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
other: Entry of the Agency for Toxic Substances and Disease Registry
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Toxicological profile for Tungsten
Author:
Keith S. et al.
Year:
2005
Bibliographic source:
Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
Reference Type:
publication
Title:
Unnamed
Year:
1982

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Tungsten hexachloride
EC Number:
236-293-9
EC Name:
Tungsten hexachloride
Cas Number:
13283-01-7
Molecular formula:
Cl6W
IUPAC Name:
tungsten hexachloride

Test animals

Species:
rabbit

Administration / exposure

Details on dermal exposure:
Single application of a 5 % Tungsten hexachloride solution
Doses:
100, 200 and 1000 mg/kg bw
No. of animals per sex per dose:
2 rabbits per dose group

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: LOAEL
Effect level:
200 mg/kg bw
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 100 - < 200 mg/kg bw
Mortality:
In the high and mid dose all animals died after dosing. No deaths in the low dose group.

Any other information on results incl. tables

No information was located regarding mechanisms involved in absorption of tungsten through the skin. However, a report of death in rabbits following a single dermal application of a 5% tungsten chloride solution (Dow Chemical Company 1982) is evidence of absorption and systemic distribution of dermally applied tungsten.

Relatively little information is available concerning adverse effects in animals following acute-duration dermal exposure to tungsten. Contact dermatitis was reported in rabbits following dermal application of a 5% tungsten chloride solution in single doses ≥100 mg/kg; doses ≥200 mg/kg also resulted in death (Dow Chemical Company 1982). Instillation of a 5% tungsten chloride solution into the rabbit eye resulted in initial ocular irritation that resolved within 14 days postinstillation (Dow Chemical Company 1982).

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
No LD50 value can be determined based on this publication.
Executive summary:

A publication of the Dow Chemical Company (1982) on the toxicological properties of Tungsten hexachloride was citied in the report of the Agency for Toxic Substances and Disease Registry (2005) on the “Toxicological profile for Tungsten”. In this study two rabbits per dose group were dermally exposed to a 5 % solution of Tungsten hexachloride in absolute doses of 100, 200 and 1000 mg/kg body weight. While all animals died in the high and mid dose groups, the animals of the low dose developed contact dermatitis. An LD50 value can not be calculated based on these data. When instilled to the eye the 5% solution of Tungsten hexachloride caused temporary ocular irritation.